ReviewThe Journal of cell biology2008
Membrane lysis during biological membrane fusion: collateral damage by misregulated fusion machines.
Review in The Journal of cell biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 41 citations in OpenAlex.
- Continuum Models of Membrane Fusion: Evolution of the Theory.International journal of molecular sciences · 2020Review
- Article
- Functional role of PGAM5 multimeric assemblies and their polymerization into filaments.Nature communications · 2019Article
- Highly Efficient Protein-free Membrane Fusion: A Giant Vesicle Study.Biophysical journal · 2019Article
- Lipid-dependence of target membrane stability during influenza viral fusion.Journal of cell science · 2018Article
- Switching between Successful and Dead-End Intermediates in Membrane Fusion.International journal of molecular sciences · 2017Article
- Cell biology of yeast zygotes, from genesis to budding.Biochimica et biophysica acta · 2015Review
- Identification and characterization of LFD-2, a predicted fringe protein required for membrane integrity during cell fusion in neurospora crassa.Eukaryotic cell · 2015Article
- Genetic basis of cell-cell fusion mechanisms.Trends in genetics : TIG · 2013Review
- Regulation of cation balance in Saccharomyces cerevisiae.Genetics · 2013Review
- Where killers meet--permeabilization of the outer mitochondrial membrane during apoptosis.Cold Spring Harbor perspectives in biology · 2013Review
- Mitofusins and the mitochondrial permeability transition: the potential downside of mitochondrial fusion.American journal of physiology. Heart and circulatory physiology · 2012Review
- Tks5-dependent formation of circumferential podosomes/invadopodia mediates cell-cell fusion.The Journal of cell biology · 2012Article
- Cardiomyocyte deletion of mitofusin-1 leads to mitochondrial fragmentation and improves tolerance to ROS-induced mitochondrial dysfunction and cell death.American journal of physiology. Heart and circulatory physiology · 2012Article
- Protein quality control in the ER: balancing the ubiquitin checkbook.Trends in cell biology · 2012Review
- Line-tension controlled mechanism for influenza fusion.PloS one · 2012Article
- Membrane fusion catalyzed by a Rab, SNAREs, and SNARE chaperones is accompanied by enhanced permeability to small molecules and by lysis.Molecular biology of the cell · 2011Article
- Cell-penetrating peptide induces leaky fusion of liposomes containing late endosome-specific anionic lipid.Biophysical journal · 2010Article
- The yeast cell fusion protein Prm1p requires covalent dimerization to promote membrane fusion.PloS one · 2010Article
- Structure of sterol aliphatic chains affects yeast cell shape and cell fusion during mating.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the canonical model of membrane fusion, the integrity of the fusing membranes is never compromised, preserving the identity of fusing compartments. However, recent molecular simulations provided evidence for a pathway to fusion in which holes in the membrane evolve into a fusion pore. Additionally, two biological membrane fusion models-yeast cell mating and in vitro vacuole fusion-have shown that modifying the composition or altering the relative expression levels of membrane fusion complexes can result in membrane lysis. The convergence of these findings showing membrane integrity loss during biological membrane fusion suggests new mechanistic models for membrane fusion and the role of membrane fusion complexes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.