ArticleMolecular and cellular biology2008
BRG1-mediated chromatin remodeling regulates differentiation and gene expression of T helper cells.
Article in Molecular and cellular biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed, 71 citations in OpenAlex.
- Blood plasma proteomics for detecting potential biomarkers for tick resistance in a tropically adapted beef cattle breed.BMC genomics · 2025Article
- STAT3 and SOX-5 induce BRG1-mediated chromatin remodeling of RORCE2 in Th17 cells.Communications biology · 2024Article
- Neuroprotective protein ADNP-dependent histone remodeling complex promotes T helper 2 immune cell differentiation.Immunity · 2023Article
- CRL4B complex-mediated H2AK119 monoubiquitination restrains Th1 and Th2 cell differentiation.Cell death and differentiation · 2023Article
- SWI/SNF chromatin remodelers in prostate cancer progression.Frontiers in epigenetics and epigenomics · 2023Review
- Targeting RIPK1 kinase for modulating inflammation in human diseases.Frontiers in immunology · 2023Review
- Pbrm1 intrinsically controls the development and effector differentiation of iNKT cells.Journal of cellular and molecular medicine · 2022Article
- Identification of novel alternative splicing associated with mastitis disease in Holstein dairy cows using large gap read mapping.BMC genomics · 2022Article
- Interplay between cofactors and transcription factors in hematopoiesis and hematological malignancies.Signal transduction and targeted therapy · 2021Review
- Re-Programming Autoreactive T Cells Into T-Regulatory Type 1 Cells for the Treatment of Autoimmunity.Frontiers in immunology · 2021Review
- Brg1 restrains the pro-inflammatory properties of ILC3s and modulates intestinal immunity.Mucosal immunology · 2021Article
- Identification of PBMC-expressed miRNAs for rheumatoid arthritis.Epigenetics · 2020Article
- Transcriptional Activation of Matricellular Protein Spondin2 (SPON2) by BRG1 in Vascular Endothelial Cells Promotes Macrophage Chemotaxis.Frontiers in cell and developmental biology · 2020Article
- Article
- Epigenetic and transcriptional mechanisms for the regulation of IL-10.Seminars in immunology · 2019Review
- ISWI ATPase Smarca5 Regulates Differentiation of Thymocytes Undergoing β-Selection.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- [Brahma-related gene 1 promotes airway mucus hypersecretion via STAT6 in asthmatic mice].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2018Article
- BPTF Is Essential for T Cell Homeostasis and Function.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Article
- Brg1 coordinates multiple processes during retinogenesis and is a tumor suppressor in retinoblastoma.Development (Cambridge, England) · 2015Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
During T helper cell differentiation, distinct programs of gene expression play a key role in defining the immune response to an environmental challenge. How chromatin remodeling events at the associated cytokine loci control differentiation is not known. We found that the ATP-dependent remodeling enzyme subunit BRG1 was required for T helper 2 (Th2) differentiation and Th2 cytokine transcription. BRG1 binding to cytokine genes was regulated by the extent of differentiation, the extent of activation, and cell fate. BRG1 was required for some features of the chromatin structure in target genes (DNase I hypersensitivity and histone acetylation), suggesting that BRG1 remodeling activity was directly responsible for changes in gene expression. NFAT and STAT6 activity were required for BRG1 recruitment to the Th2 locus control region, and STAT6 associated with BRG1 in a differentiation-inducible manner, suggesting direct recruitment of BRG1 to the bound loci. Together, these findings suggest BRG1 interprets differentiation signals and plays a causal role in gene regulation, chromatin structure, and cell fate.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.