ArticleAntimicrobial agents and chemotherapy2008
Lysine-enriched cecropin-mellitin antimicrobial peptides with enhanced selectivity.
Article in Antimicrobial agents and chemotherapy, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- Chemical Synthesis of Medin via a Removable Aggregation-Suppressing Linker.Journal of peptide science : an official publication of the European Peptide Society · 2025Article
- Designing Novel Antimicrobial Agents from the Synthetic Antimicrobial Peptide (Pep-38) to Combat Antibiotic Resistance.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Synthesis of Temporin-SHa Retro Analogs with Lysine Addition/Substitution and Antibiotic Conjugation to Enhance Antibacterial, Antifungal, and Anticancer Activities.Antibiotics (Basel, Switzerland) · 2024Article
- Recent biotechnological applications of value-added bioactive compounds from microalgae and seaweeds.Botanical studies · 2024Review
- The bactericidal and antibiofilm effects of a lysine-substituted hybrid peptide, CM-10K14K, on biofilm-forming Staphylococcus epidermidis.Scientific reports · 2023Article
- Discovering highly potent antimicrobial peptides with deep generative model HydrAMP.Nature communications · 2023Article
- Tuning the Anthranilamide Peptidomimetic Design to Selectively Target Planktonic Bacteria and Biofilm.Antibiotics (Basel, Switzerland) · 2023Article
- Enhanced therapeutic window for antimicrobial Pept-ins by investigating their structure-activity relationship.PloS one · 2023Article
- Membrane fluidity, composition, and charge affect the activity and selectivity of the AMP ascaphin-8.Biophysical journal · 2022Article
- OMN6 a novel bioengineered peptide for the treatment of multidrug resistant Gram negative bacteria.Scientific reports · 2021Article
- CxxC Zinc Finger Protein Derived Peptide, MF18 Functions Against Biofilm Formation.The protein journal · 2020Article
- Physicochemical-guided design of cathelicidin-derived peptides generates membrane active variants with therapeutic potential.Scientific reports · 2020Article
- Identification of Antimicrobial Peptides from the MicroalgaeMarine drugs · 2019Article
- Manipulating Active Structure and Function of Cationic Antimicrobial Peptide CM15 with the Polysulfonated Drug Suramin: A Step Closer to in Vivo Complexity.Chembiochem : a European journal of chemical biology · 2019Article
- Understanding the antimicrobial properties/activity of an 11-residue Lys homopeptide by alanine and proline scan.Amino acids · 2018Article
- Identification, characterization, and recombinant expression of epidermicin NI01, a novel unmodified bacteriocin produced by Staphylococcus epidermidis that displays potent activity against Staphylococci.Antimicrobial agents and chemotherapy · 2012Article
- The Design and Construction of K11: A Novel α-Helical Antimicrobial Peptide.International journal of microbiology · 2012Article
- Using infrared spectroscopy of cyanylated cysteine to map the membrane binding structure and orientation of the hybrid antimicrobial peptide CM15.Biochemistry · 2011Article
- Effects of D-Lysine Substitutions on the Activity and Selectivity of Antimicrobial Peptide CM15.Polymers · 2011Article
- Expression of recombinant hybrid peptide hinnavin II/alpha-melanocyte-stimulating hormone in Escherichia coli: purification and characterization.Journal of microbiology (Seoul, Korea) · 2010Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Lysine-enriched analogs of the cecropin-mellitin hybrid peptide, CA(1-7) M(2-9) (designated CM15), designed with optimized amphipathicity, retained antimicrobial activities similar to that of wild-type CM15 and had substantially reduced levels of hemolytic activity and cytotoxicity toward cultured macrophages, resulting in enhanced selectivity. These lysine-enriched analogs provide templates for improved CM15 peptide or peptidomimetic antibiotics.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.