ArticleThe Journal of biological chemistry2008
Ascorbate peroxidase 1 plays a key role in the response of Arabidopsis thaliana to stress combination.
Article in The Journal of biological chemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 144 papers.
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Who cites it
144 citing papers in PubMed, 406 citations in OpenAlex.
- Loss ofPlants (Basel, Switzerland) · 2026Article
- Genomics, Multi-Omics, and Emerging Artificial Intelligence for Combined Drought-Heat Stress Resilience in Plants: A Structured Narrative Review.Plants (Basel, Switzerland) · 2026Review
- Heat and Drought Co-Stress During Microgametogenesis Altered Pollen Development, Fertility and Grain Production in Two-Rowed Winter Barley.Plants (Basel, Switzerland) · 2026Article
- Conserved 4-coumarate 3-hydroxylase/ascorbate peroxidase bifunctionality coordinates lignin deposition and plant growth in Brachypodium and Populus.Plant physiology · 2026Article
- Genome-wide characterization of soybean alcohol dehydrogenase (ADH) genes identifies GmADH13 as a positive regulator of the salt stress response.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Article
- Comparative analysis of synteny and functional divergence of APX genes in Fragaria vesca and Fragaria×ananassa.BMC plant biology · 2025Article
- Genome-wide analysis of ascorbate peroxidase and functional characterization of SpAPX249b and SpAPX285c for salt tolerance in Sesuvium portulacastrum L.Plant cell reports · 2025Article
- Article
- Distinct transcriptomic strategies underlie differential heat tolerance in Symbiodiniaceae symbionts.The ISME journal · 2025Article
- Seed priming with plant waste extracts enhances maize drought tolerance in a genotype-specific manner.Frontiers in plant science · 2025Article
- Decoding the role of durum wheat ascorbate peroxidase TdAPX7B-2 in abiotic stress response.Functional & integrative genomics · 2024Article
- Research Progress on Plant Responses to Stress Combinations in the Context of Climate Change.Plants (Basel, Switzerland) · 2024Review
- Unveiling the role of epigenetic mechanisms and redox signaling in alleviating multiple abiotic stress in plants.Frontiers in plant science · 2024Review
- Drought Resistance and Ginsenosides Biosynthesis in Response to Abscisic Acid inInternational journal of molecular sciences · 2023Article
- Biochemical responses in leaf tissues of alkaloid producing Psychotria brachyceras under multiple stresses.Journal of plant research · 2023Article
- Massive increases in C31 alkane on Zygophyllum xanthoxylum leaves contribute to its excellent abiotic stress tolerance.Annals of botany · 2023Article
- A role for heritable transcriptomic variation in maize adaptation to temperate environments.Genome biology · 2023Article
- Kinase Inhibitor VvBKI1 Interacts with Ascorbate Peroxidase VvAPX1 Promoting Plant Resistance to Oomycetes.International journal of molecular sciences · 2023Article
- Redox Signaling in Plant Heat Stress Response.Antioxidants (Basel, Switzerland) · 2023Review
84 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Within their natural habitat plants are subjected to a combination of different abiotic stresses, each with the potential to exacerbate the damage caused by the others. One of the most devastating stress combinations for crop productivity, which frequently occurs in the field, is drought and heat stress. In this study we conducted proteomic and metabolic analysis of Arabidopsis thaliana plants subjected to a combination of drought and heat stress. We identified 45 different proteins that specifically accumulated in Arabidopsis in response to the stress combination. These included enzymes involved in reactive oxygen detoxification, malate metabolism, and the Calvin cycle. The accumulation of malic enzyme during the combined stress corresponded with enhanced malic enzyme activity, a decrease in malic acid, and lower amounts of oxaloacetate, suggesting that malate metabolism plays an important role in the response of Arabidopsis to the stress combination. Cytosolic ascorbate peroxidase 1 (APX1) protein and mRNA accumulated during the stress combination. When exposed to heat stress combined with drought, an APX1-deficient mutant (apx1) accumulated more hydrogen peroxide and was significantly more sensitive to the stress combination than wild type. In contrast, mutants deficient in thylakoid or stromal/mitochondrial APXs were not more sensitive to the stress combination than apx1 or wild type. Our findings suggest that cytosolic APX1 plays a key role in the acclimation of plants to a combination of drought and heat stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.