ArticleInfection and immunity2008
Vaccine-induced cellular immune responses differ from innate responses in susceptible and resistant strains of mice infected with Coccidioides posadasii.
Article in Infection and immunity, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed.
- Current perspectives of host-pathogen dynamics in coccidioidomycosis.Current opinion in microbiology · 2026Review
- A treatment monitoring protocol to determine clinical remission in dogs with pulmonary coccidioidomycosis.Journal of veterinary internal medicine · 2026Article
- Article
- Genetic and Other Determinants for the Severity of Coccidioidomycosis: A Clinician's Perspective.Journal of fungi (Basel, Switzerland) · 2023Review
- B Cell Chronic Lymphocytic Leukemia Development in Mice with Chronic Lung Exposure to Coccidioides Fungal Arthroconidia.ImmunoHorizons · 2023Article
- Volatile Metabolites in Lavage Fluid Are Correlated with Cytokine Production in a Valley Fever Murine Model.Journal of fungi (Basel, Switzerland) · 2023Article
- Reactivation of Coccidioidomycosis in a Mouse Model of Asymptomatic Controlled Disease.Journal of fungi (Basel, Switzerland) · 2022Article
- Vaccines to Prevent Coccidioidomycosis: A Gene-Deletion Mutant of Coccidioides Posadasii as a Viable Candidate for Human Trials.Journal of fungi (Basel, Switzerland) · 2022Review
- Article
- A Chronic Murine Disease Model of Coccidioidomycosis Using Coccidioides posadasii, Strain 1038.The Journal of infectious diseases · 2021Article
- Defining Critical Genes During Spherule Remodeling and Endospore Development in the Fungal Pathogen,Frontiers in genetics · 2020Article
- The Role of the Interleukin-17 Axis and Neutrophils in the Pathogenesis of Endemic and Systemic Mycoses.Frontiers in cellular and infection microbiology · 2020Review
- Early Events in Coccidioidomycosis.Clinical microbiology reviews · 2019Review
- A review of innate and adaptive immunity to coccidioidomycosis.Medical mycology · 2019Review
- Myeloid Differentiation Factor 88 and Interleukin-1R1 Signaling Contribute to Resistance to Coccidioides immitis.Infection and immunity · 2018Article
- Immune Response to Coccidioidomycosis and the Development of a Vaccine.Microorganisms · 2017Review
- A Coccidioides posadasii CPS1 Deletion Mutant Is Avirulent and Protects Mice from Lethal Infection.Infection and immunity · 2016Article
- Flow Cytometric Analysis of Protective T-Cell Response Against Pulmonary Coccidioides Infection.Methods in molecular biology (Clifton, N.J.) · 2016Article
- Article
- Differences in Host Innate Responses among Coccidioides Isolates in a Murine Model of Pulmonary Coccidioidomycosis.Eukaryotic cell · 2015Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Susceptibility to Coccidioides spp. varies widely in humans and other mammals and also among individuals within a species. Among strains of mice with various susceptibilities, immunohistopathology revealed that C57BL/6 mice were highly susceptible to the disease following intranasal infection, DBA/2n mice were intermediate, and Swiss-Webster mice were innately resistant. Resistant Swiss-Webster mice developed prominent perivascular/peribronchiolar lymphocytic cuffing and well-formed granulomas with few fungal elements and debris in the necrotic center, surrounded by a mantle of macrophages, lymphocytes, and fibrocytes. Susceptible C57BL/6 mice became moribund between 14 and 18 days postinfection, with overwhelming numbers of neutrophils and spherules and very few T cells, the drastic reduction of which was associated with failure and death, while intermediate DBA/2n mice controlled the fungal burden but demonstrated progressive lung inflammation with prominent suppuration, and they deteriorated clinically. Vaccinated C57BL/6 mice had an early and robust lymphocyte response, which included significantly higher Mac2(+), CD3(+), and CD4(+) cell scores on day 18 than those of innately resistant SW mice and DBA/2n mice; they also had prominent perivascular/peribronchiolar lymphocytic infiltrates not present in their unvaccinated counterparts, and they appeared to be resolving lesions by day 56 compared to the other two strains, based on significantly lower disease scores and observably smaller and fewer lesions with few spherules and neutrophils.
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