ReviewHuman molecular genetics2008
Genome-wide association studies: implications for multiethnic samples.
Review in Human molecular genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Transancestral fine-mapping of four type 2 diabetes susceptibility loci highlights potential causal regulatory mechanisms.Human molecular genetics · 2016Pooled it
- Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.Nature genetics · 2014Pooled it
- Replication and fine mapping of asthma-associated loci in individuals of African ancestry.Human genetics · 2013Pooled it
- Implication of European-derived adiposity loci in African Americans.International journal of obesity (2005) · 2012Pooled it
- Genome-wide association study of body height in African Americans: the Women's Health Initiative SNP Health Association Resource (SHARe).Human molecular genetics · 2012Pooled it
- Pooled it
- Transethnic meta-analysis of genomewide association studies.Genetic epidemiology · 2011Pooled it
- Common genetic variants associated with resting oxygenation in chronic obstructive pulmonary disease.American journal of respiratory cell and molecular biology · 2014Trial
- Genetic architecture of multiple myeloma: From somatic alterations to germline susceptibility and clinical implications.Translational oncology · 2026Review
- A Study of Candidate Genes Associated with Suicide Attempts in the Kazakh Population in Astana, Kazakhstan.International journal of molecular sciences · 2026Article
- Addressing myocardial infarction in South-Asian populations: risk factors and machine learning approaches.NPJ cardiovascular health · 2025Review
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- APOC3 genetic variation, serum triglycerides, and risk of coronary artery disease in Asian Indians, Europeans, and other ethnic groups.Lipids in health and disease · 2021Article
- Genetic and Non-genetic Determinants of Cardiovascular Disease in South Asians.Current diabetes reviews · 2021Review
- A rare missense variant in the milk fat globule-EGF factor 8 (MFGE8) increases T2DM susceptibility and cardiovascular disease risk with population-specific effects.Acta diabetologica · 2020Article
- Cross-population analysis for functional characterization of type II diabetes variants.BMC bioinformatics · 2019Article
- Clinical Utility and Practical Considerations of a Coronary Artery Disease Genetic Risk Score.CJC open · 2019Article
- Article
- An Ancestry Informative Marker Set Which Recapitulates the Known Fine Structure of Populations in South Asia.Genome biology and evolution · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The current gene mapping for complex diseases is heavily weighted by studies of population samples from northern Europe. To capture the full range of genetic diversity and exploit the potential of genetic epidemiology to identify important variants, multiple additional populations will need to be examined. The conduct of genome-wide association studies will therefore confront many of the challenges identified in the first generation of candidate gene and linkage studies, with a substantial increase in complexity. Initial efforts to map causal effects will have to take account of varying patterns of linkage disequilibrium through careful attention to local haplotype structure. Refined statistical techniques that permit joint analyses of samples from multiple populations will also be required, as well as improved methods to account for on-going gene flow between populations with geographically distinct ancestral origins. This variation can either be an impediment, slowing the process of replication, or an opportunity, allowing finer dissection of the relevant variants. Clinical translation of these data will present major challenges. Large cosmopolitan populations, such as those found in large urban centers, are likely to exhibit both known and cryptic sub-structure across groups, as well as admixture within individuals. Great care will need to be devoted to generalizability of association findings to avoid their premature adoption as predictive tests in the face of this widespread heterogeneity.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.