ArticleExperimental gerontology2008
Effect of aging, caloric restriction, and uncoupling protein 3 (UCP3) on mitochondrial proton leak in mice.
Article in Experimental gerontology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 39 citations in OpenAlex.
- Recovery of SIRT3-SOD2 Axis and Mitophagy by Short-Term Calorie Restriction in Old Rat Soleus Skeletal Muscle.Antioxidants (Basel, Switzerland) · 2025Article
- Adipose Tissue, Non-Communicable Diseases, and Physical Exercise: An Imperfect Triangle.International journal of molecular sciences · 2023Review
- Antimicrobial mitochondrial reactive oxygen species induction by lung epithelial immunometabolic modulation.PLoS pathogens · 2023Article
- Mitochondrial proton leak in cardiac aging.GeroScience · 2023Review
- Antimicrobial mitochondrial reactive oxygen species induction by lung epithelial metabolic reprogramming.bioRxiv : the preprint server for biology · 2023Article
- Selenoproteins and the senescence-associated epitranscriptome.Experimental biology and medicine (Maywood, N.J.) · 2022Review
- Mitochondrial electron transport chain: Oxidative phosphorylation, oxidant production, and methods of measurement.Redox biology · 2020Review
- Exercise Effects on Mitochondrial Function and Lipid Metabolism during Energy Balance.Medicine and science in sports and exercise · 2020Article
- Effects of Aging and Caloric Restriction on Fiber Type Composition, Mitochondrial Morphology and Dynamics in Rat Oxidative and Glycolytic Muscles.Frontiers in physiology · 2019Article
- The influence of dietary fat source on liver and skeletal muscle mitochondrial modifications and lifespan changes in calorie-restricted mice.Biogerontology · 2015Review
- Collaboration between mitochondria and the nucleus is key to long life in Caenorhabditis elegans.Free radical biology & medicine · 2015Review
- Metabolic adaptation to weight loss: implications for the athlete.Journal of the International Society of Sports Nutrition · 2014Article
- The influence of dietary lipid composition on skeletal muscle mitochondria from mice following eight months of calorie restriction.Physiological research · 2014Article
- Mitochondrial dynamics in the regulation of nutrient utilization and energy expenditure.Cell metabolism · 2013Review
- Cancer cachexia is associated with a decrease in skeletal muscle mitochondrial oxidative capacities without alteration of ATP production efficiency.Journal of cachexia, sarcopenia and muscle · 2012Article
- The influence of dietary lipid composition on skeletal muscle mitochondria from mice following 1 month of calorie restriction.The journals of gerontology. Series A, Biological sciences and medical sciences · 2012Article
- Metabolic switching and fuel choice during T-cell differentiation and memory development.Immunological reviews · 2012Review
- Calorie restriction in mice overexpressing UCP3: evidence that prior mitochondrial uncoupling alters response.Experimental gerontology · 2012Article
- Caloric restriction and redox state: does this diet increase or decrease oxidant production?Redox report : communications in free radical research · 2011Review
- Metabolic reprogramming, caloric restriction and aging.Trends in endocrinology and metabolism: TEM · 2010Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Mitochondrial proton leak may modulate reactive oxygen species (ROS) production and play a role in aging. The purpose of this study was to determine proton leak across the life span in skeletal mitochondria from calorie-restricted and UCP2/3 overexpressing mice. Proton leak in isolated mitochondria and markers of oxidative stress in whole tissue were measured in female C57BL/6J mice fed ad-libitum (WT-Control) or a 30% calorie-restricted (WT-CR) diet, and in mice overexpressing UCP2 and UCP3 (Positive-TG), their non-overexpressing littermates (Negative-TG) and UCP3 knockout mice (UCP3KO). Proton leak in WT-CR mice was lower than that of control mice at 8 and 26 months of age. The Positive-TG mice had greater proton leak than the Negative-TG and UCP3KO mice at 8 months of age, but this difference disappeared by 19 and 26 months. Lipid peroxidation was generally lower in WT-CR vs. WT-Control mice and UCP3KO mice had greater concentrations of T-BARS (thiobarbituric acid reactive substances, a measure of lipid peroxidation) than did Positive-TG and Negative-TG. The results of this study indicate that sustained increases in muscle mitochondrial proton leak are not responsible for alterations in life span with calorie restriction or UCP3 overexpression in mice. However, UCP3 may contribute to the actions of CR through mechanisms distinct from increasing basal proton leak.
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Registered trials
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