ArticleMolecular cell2008
Bimodal protein targeting through activation of cryptic mitochondrial targeting signals by an inducible cytosolic endoprotease.
Article in Molecular cell, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 44 citations in OpenAlex.
- Interactions of amyloidogenic proteins with mitochondrial protein import machinery in aging-related neurodegenerative diseases.Frontiers in physiology · 2023Review
- Mitochondrial Glucocorticoid Receptors and Their Actions.International journal of molecular sciences · 2021Review
- Proteasomal degradation induced by DPP9-mediated processing competes with mitochondrial protein import.The EMBO journal · 2020Article
- Article
- Signaling and Regulation of the Mitochondrial Unfolded Protein Response.Cold Spring Harbor perspectives in biology · 2019Review
- Reactive oxygen species stress increases accumulation of tyrosyl-DNA phsosphodiesterase 1 within mitochondria.Scientific reports · 2018Article
- TP53 mutation, mitochondria and cancer.Current opinion in genetics & development · 2016Review
- p53 as guardian of the mitochondrial genome.FEBS letters · 2016Review
- Mitochondrial targeting of cytochrome P450 (CYP) 1B1 and its role in polycyclic aromatic hydrocarbon-induced mitochondrial dysfunction.The Journal of biological chemistry · 2014Article
- Acute exercise induces tumour suppressor protein p53 translocation to the mitochondria and promotes a p53-Tfam-mitochondrial DNA complex in skeletal muscle.The Journal of physiology · 2013Article
- Mitochondrial translocation of vitamin D receptor is mediated by the permeability transition pore in human keratinocyte cell line.PloS one · 2013Article
- Bimodal targeting of cytochrome P450s to endoplasmic reticulum and mitochondria: the concept of chimeric signals.The FEBS journal · 2011Review
- Compartment-restricted biotinylation reveals novel features of prion protein metabolism in vivo.Molecular biology of the cell · 2010Article
- Bimodal targeting of microsomal cytochrome P450s to mitochondria: implications in drug metabolism and toxicity.Expert opinion on drug metabolism & toxicology · 2010Review
- Ligand-independent antiapoptotic function of estrogen receptor-beta in lung cancer cells.Molecular endocrinology (Baltimore, Md.) · 2010Article
- Mitochondria-targeted cytochrome P450 2E1 induces oxidative damage and augments alcohol-mediated oxidative stress.The Journal of biological chemistry · 2010Article
- From bioblasts to mitochondria: ever expanding roles of mitochondria in cell physiology.Frontiers in physiology · 2010Article
- Mitochondrial trafficking of APP and alpha synuclein: Relevance to mitochondrial dysfunction in Alzheimer's and Parkinson's diseases.Biochimica et biophysica acta · 2010Review
- Mitochondrial accumulation of APP and Abeta: significance for Alzheimer disease pathogenesis.Journal of cellular and molecular medicine · 2009Review
- p53 improves aerobic exercise capacity and augments skeletal muscle mitochondrial DNA content.Circulation research · 2009Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Bimodal targeting of the endoplasmic reticular protein, cytochrome P4501A1 (CYP1A1), to mitochondria involves activation of a cryptic mitochondrial targeting signal through endoprotease processing of the protein. Here, we characterized the endoprotease that regulates mitochondrial targeting of CYP1A1. The endoprotease, which was induced by beta-naphthoflavone, was a dimer of 90 kDa and 40 kDa subunits, each containing Ser protease domains. The purified protease processed CYP1A1 in a sequence-specific manner, leading to its mitochondrial import. The glucocorticoid receptor, retinoid X receptor, and p53 underwent similar processing-coupled mitochondrial transport. The inducible 90 kDa subunit was a limiting factor in many cells and some tissues and, thus, regulates the mitochondrial levels of these proteins. A number of other mitochondria-associated proteins with noncanonical targeting signals may also be substrates of this endoprotease. Our results describe a new mechanism of mitochondrial protein import that requires an inducible cytoplasmic endoprotease for activation of cryptic mitochondrial targeting signals.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.