ArticleBMC molecular biology2008
New insights into SRY regulation through identification of 5' conserved sequences.
Article in BMC molecular biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 22 citations in OpenAlex.
- A conserved NR5A1-responsive enhancer regulates SRY in testis-determination.Nature communications · 2024Article
- The Contribution of Y Chromosome Genes to Spontaneous Differentiation of Human Embryonic Stem Cells into Embryoid BodiesCell journal · 2021Article
- Single Nucleotide Polymorphisms ofGenes · 2019Article
- The evolutionary process of mammalian sex determination genes focusing on marsupial SRYs.BMC evolutionary biology · 2018Article
- Conservation analysis of sequences flanking the testis-determining gene Sry in 17 mammalian species.BMC developmental biology · 2015Article
- Switching on sex: transcriptional regulation of the testis-determining gene Sry.Development (Cambridge, England) · 2014Review
- Y-chromosome phylogeny in the evolutionary net of chamois (genus Rupicapra).BMC evolutionary biology · 2011Article
- Molecular cloning and characterization of the porcine FTO promoter and coding regions.Molecular biology reports · 2011Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSRY is the pivotal gene initiating male sex determination in most mammals, but how its expression is regulated is still not understood. In this study we derived novel SRY 5' flanking genomic sequence data from bovine and caprine genomic BAC clones.
resultsWe identified four intervals of high homology upstream of SRY by comparison of human, bovine, pig, goat and mouse genomic sequences. These conserved regions contain putative binding sites for a large number of known transcription factor families, including several that have been implicated previously in sex determination and early gonadal development.
conclusionOur results reveal potentially important SRY regulatory elements, mutations in which might underlie cases of idiopathic human XY sex reversal.
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