ArticleBMC endocrine disorders2008
The AQUA-FONTIS study: protocol of a multidisciplinary, cross-sectional and prospective longitudinal study for developing standardized diagnostics and classification of non-thyroidal illness syndrome.
Article in BMC endocrine disorders, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Development of Rational and Standardized Diagnostics and Staging for a Differentiated Risk Stratification of Non-thyroidal Illness Syndrome
Observational and Diagnostical Study on Transient Allostatic Responses of Thyroid Function After Cardiopulmonary Resuscitation
Observational and Diagnostical Study on Transient Allostatic Responses of Thyroid Function After Syncopation and Seizure (Thyro-Syncope)
Who cites it
22 citing papers in PubMed, 43 citations in OpenAlex.
- Serum reverse triiodothyronine in dogs with hypothyroidism, nonthyroidal illness syndrome and healthy dogs.PloS one · 2026Article
- Ustekinumab may have therapeutic effects on autoimmune thyroid disease.Scientific reports · 2025Article
- Article
- Usefulness of SPINA model in evaluation of the thyroid function in euthyroid pediatric patients children with subclinical hypothyroidism.Frontiers in endocrinology · 2025Article
- Prognostic significance of thyroid hormone T3 in patients with septic shock: a retrospective cohort study.PeerJ · 2023Article
- Nickel as a potential disruptor of thyroid function: benchmark modelling of human data.Frontiers in endocrinology · 2023Article
- Decreased deiodinase activity after glucose load could lead to atherosclerosis in euthyroid women with polycystic ovary syndrome.Endocrine · 2019Article
- Calcification Patterns in Papillary Thyroid Carcinoma are Associated with Changes in Thyroid Hormones and Coronary Artery Calcification.Journal of clinical medicine · 2018Article
- Editorial: "Homeostasis and Allostasis of Thyroid Function".Frontiers in endocrinology · 2018Article
- Changes in Body Compositions and Basal Metabolic Rates during Treatment of Graves' Disease.International journal of endocrinology · 2018Article
- Dual control of pituitary thyroid stimulating hormone secretion by thyroxine and triiodothyronine in athyreotic patients.Therapeutic advances in endocrinology and metabolism · 2017Article
- Advances in applied homeostatic modelling of the relationship between thyrotropin and free thyroxine.PloS one · 2017Article
- Thyroid Allostasis-Adaptive Responses of Thyrotropic Feedback Control to Conditions of Strain, Stress, and Developmental Programming.Frontiers in endocrinology · 2017Review
- Relational Stability of Thyroid Hormones in Euthyroid Subjects and Patients with Autoimmune Thyroid Disease.European thyroid journal · 2016Article
- Low Triiodothyronine Syndrome in Patients With Radiation Enteritis: Risk Factors and Clinical Outcomes an Observational Study.Medicine · 2016Observational
- Calculated Parameters of Thyroid Homeostasis: Emerging Tools for Differential Diagnosis and Clinical Research.Frontiers in endocrinology · 2016Article
- Low T3 syndrome and long-term mortality in chronic hemodialysis patients.World journal of nephrology · 2015Article
- Nonthyroidal Illness Syndrome in Cardiac Illness Involves Elevated Concentrations of 3,5-Diiodothyronine and Correlates with Atrial Remodeling.European thyroid journal · 2015Article
- [Thyroid storm].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2012Review
- Relationship between thyroid function and ICU mortality: a prospective observation study.Critical care (London, England) · 2012Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNon-thyroidal illness syndrome (NTIS) is a characteristic functional constellation of thyrotropic feedback control that frequently occurs in critically ill patients. Although this condition is associated with significantly increased morbidity and mortality, there is still controversy on whether NTIS is caused by artefacts, is a form of beneficial adaptation, or is a disorder requiring treatment. Trials investigating substitution therapy of NTIS revealed contradictory results. The comparison of heterogeneous patient cohorts may be the cause for those inconsistencies.
objectivesPrimary objective of this study is the identification and differentiation of different functional states of thyrotropic feedback control in order to define relevant evaluation criteria for the prognosis of affected patients. Furthermore, we intend to assess the significance of an innovative physiological index approach (SPINA) in differential diagnosis between NTIS and latent (so-called "sub-clinical") thyrotoxicosis.Secondary objective is observation of variables that quantify distinct components of NTIS in the context of independent predictors of evolution, survival or pathophysiological condition and influencing or disturbing factors like medication.
designThe approach to a quantitative follow-up of non-thyroidal illness syndrome (AQUA FONTIS study) is designed as both a cross-sectional and prospective longitudinal observation trial in critically ill patients. Patients are observed in at least two evaluation points with consecutive assessments of thyroid status, physiological and clinical data in additional weekly observations up to discharge. A second part of the study investigates the neuropsychological impact of NTIS and medium-term outcomes.The study design incorporates a two-module structure that covers a reduced protocol in form of an observation trial before patients give informed consent. Additional investigations are performed if and after patients agree in participation.
trial registrationClinicalTrials.gov NCT00591032.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.