ArticlePhysical review. E, Statistical, nonlinear, and soft matter physics2008
Atomic force microscopy analysis of cell volume regulation.
Article in Physical review. E, Statistical, nonlinear, and soft matter physics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The trial behind it
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Who cites it
34 citing papers in PubMed.
- Mechanosensitive Ion Channels: The Unending Riddle of Mechanotransduction.Bioelectricity · 2025Review
- Osmotic Pressure and Its Biological Implications.International journal of molecular sciences · 2024Review
- Vascular mechanotransduction.Physiological reviews · 2023Review
- Changes in cell surface properties ofFEMS microbes · 2023Article
- Hypotonic Challenge of Endothelial Cells Increases Membrane Stiffness with No Effect on Tether Force.Biophysical journal · 2018Article
- Mechanical Transduction and the Dark Energy of Biology.Biophysical journal · 2018Review
- Membrane Stiffening in Osmotic Swelling: Analysis of Membrane Tension and Elastic Modulus.Current topics in membranes · 2018Article
- Brain tissue stiffness is a sensitive marker for acidosis.Journal of neuroscience methods · 2016Article
- Characterizing Cellular Biophysical Responses to Stress by Relating Density, Deformability, and Size.Biophysical journal · 2015Article
- Mechanical transduction by ion channels: A cautionary tale.World journal of neurology · 2015Article
- Cell volume control in three dimensions: Water movement without solute movement.The Journal of general physiology · 2015Article
- Salt and osmosensing: role of cytoplasmic hydrogel.Pflugers Archiv : European journal of physiology · 2015Review
- Actin stress in cell reprogramming.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Fluorescence-based force/tension sensors: a novel tool to visualize mechanical forces in structural proteins in live cells.Antioxidants & redox signaling · 2014Review
- Human PIEZO1: removing inactivation.Biophysical journal · 2013Article
- Silicon chips detect intracellular pressure changes in living cells.Nature nanotechnology · 2013Article
- The cytoplasm of living cells behaves as a poroelastic material.Nature materials · 2013Article
- Human AQP1 is a constitutively open channel that closes by a membrane-tension-mediated mechanism.Biophysical journal · 2013Article
- Mechanosensitive TRPC1 channels promote calpain proteolysis of talin to regulate spinal axon outgrowth.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Cells swell in response a hypoosmotic challenge. By converting osmotic pressure to hydrostatic pressure at the cell membrane via van't Hoff's law, and converting that to tension via Laplace's law one predicts that the cell membrane should stretch and become stiff. We tested this prediction using the atomic force microscopy. During osmotic swelling cells did not become stiff and generally became softer. This result contradicts the assumption of the cell membrane as the constraining element in osmotic stress but is consistent with the cytoskeleton acting as a cross-linked gel. Models of the cells' response to osmotic stress must include energy terms for three-dimensional stresses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.