ArticleGenes & nutrition2006
Evolutionary conservation of metabolism explains howDrosophila nutrigenomics can help us understand human nutrigenomics.
Article in Genes & nutrition, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Gallic Acid, 3-Hydroxytyrosol, and Quercetin Modulate Cholinesterase Activity inInternational journal of molecular sciences · 2026Article
- Review
- A Buoyancy-based Method of Determining Fat Levels in Drosophila.Journal of visualized experiments : JoVE · 2016Article
- Epigallocatechin gallate affects glucose metabolism and increases fitness and lifespan in Drosophila melanogaster.Oncotarget · 2015Article
- Dietary intake of Curcuma longa and Emblica officinalis increases life span in Drosophila melanogaster.BioMed research international · 2014Article
- Drosophila lacks C20 and C22 PUFAs.Journal of lipid research · 2010Article
- The challenges for molecular nutrition research 3: comparative nutrigenomics research as a basis for entering the systems level.Genes & nutrition · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
While large populations in the third world are enduring famine, much of the developed world is undergoing an obesity epidemic. In addition to reflecting an unbalanced distribution of food, the "epidemic of overabundance" is ironically leading to a decrease in the health and longevity of the obese and improperly nourished in the first world. International consortia, such as the European Nutrigenomics Organization (NuGO), are increasing our knowledge of nutrientgene interactions and the effects of diet and obesity on human health. In this review, we summarize both previous and ongoing nutrigenomics studies in Drosophila and we explain how these studies can be used to provide insights into molecular mechanisms underlying nutrigenomics in humans. We will discuss how quantitative trait locus (QTL) experiments have identified genes that affect triglyceride levels in Drosophila, and how microarray analyses show that hundreds of genes have altered gene expression under different dietary conditions. Finally, we will discuss ongoing combined microarray-QTL studies, termed "genetical genomics," that promise to identify "master modulatory loci" that regulate global responses of potentially hundreds of genes under different dietary conditions. When "master modulatory loci" are identified in Drosophila, then experiments in mammalian models can be used to determine the relevance of these genes to human nutrition and health.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.