ArticleGenes & nutrition2007
Adverse effects of vitamin E by induction of drug metabolism.
Article in Genes & nutrition, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 6 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- Vitamin E, Alpha-Tocopherol, and Its Effects on Depression and Anxiety: A Systematic Review and Meta-Analysis.Nutrients · 2022Pooled it
- Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid and late life.The Cochrane database of systematic reviews · 2018Pooled it
- Vitamin and mineral supplementation for preventing dementia or delaying cognitive decline in people with mild cognitive impairment.The Cochrane database of systematic reviews · 2018Pooled it
- Vitamin E for Alzheimer's dementia and mild cognitive impairment.The Cochrane database of systematic reviews · 2017Pooled it
- Vitamin E for Alzheimer's dementia and mild cognitive impairment.The Cochrane database of systematic reviews · 2017Pooled it
- Vitamin E for Alzheimer's dementia and mild cognitive impairment.The Cochrane database of systematic reviews · 2012Pooled it
- Oxidized vitamin E metabolites during infancy and childhood asthma risk: too little, too much, or just right?American journal of respiratory and critical care medicine · 2026Article
- Transporters in vitamin uptake and cellular metabolism: impacts on health and disease.Life metabolism · 2025Review
- Article
- Beneficial and adverse effects of vitamin E on the kidney.Frontiers in physiology · 2023Review
- Molecular Mechanisms Underlying the Therapeutic Role of Vitamin E in Age-Related Macular Degeneration.Frontiers in neuroscience · 2022Review
- Utilization of redox modulating small molecules that selectively act as pro-oxidants in cancer cells to open a therapeutic window for improving cancer therapy.Redox biology · 2021Review
- Article
- Bladder cancer: total antioxidant capacity and pharmacotherapy with vitamin-E.International urology and nephrology · 2020Article
- Antioxidant diet and sex interact to regulate NOS isoform expression and glomerular mesangium proliferation in Zucker diabetic rat kidney.Acta histochemica · 2016Article
- A metabolomic investigation of the effects of vitamin E supplementation in humans.Nutrition & metabolism · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Observational studies with healthy persons demonstrated an inverse association of vitamin E with the risk of coronary heart disease or cancer, the outcome of large-scale clinical trials conducted to prove a benefit of vitamin E in the recurrence and/or progression of such disease, however, was disappointing. Vitamin E did not provide benefits to patients with cardiovascular diseases, cancer, diabetes or hypertension. Even harmful events and worsening of pre-existing diseases were reported, which are hard to explain. Since vitamin E is metabolized along the same routes as xenobiotics and induces drug-metabolizing enzymes in rodents, it is hypothesized that a supplementation with high dosages of vitamin E may also lead to an induction of the drug-metabolizing system in patients that depend on drug therapy. Compromising essential therapy might therefore outweigh any benefit of vitamin E in patients. It is recommended to work out at which threshold the drug-metabolizing system can be induced in humans before new trials with high dosages of vitamin E are started.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.