ArticleNature2008
The ion pathway through the opened Na(+),K(+)-ATPase pump.
Article in Nature, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed.
- Designable van der Waals Crystal for Artificial Neuronal Cell Mimicking.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- NaFrontiers in chemistry · 2026Article
- How palytoxin transforms the NaProceedings of the National Academy of Sciences of the United States of America · 2025Article
- NaInternational journal of molecular sciences · 2024Review
- Structural-functional aberrations of erythrocytes in the northern red-backed vole (Clethrionomys rutilus Pallas, 1779) that inhabits the zone of influence of the copper smelter (the Middle Ural).Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2023Article
- Role of NaJournal of molecular medicine (Berlin, Germany) · 2022Review
- An Intracellular Pathway Controlled by the N-terminus of the Pump Subunit Inhibits the Bacterial KdpFABC Ion Pump in High KJournal of molecular biology · 2021Article
- Effect of a purine derivative containing selenium to improve memory decline and anxiety through modulation of the cholinergic system and NaMetabolic brain disease · 2021Article
- Genotype-structure-phenotype relationships diverge in paralogsNeurology. Genetics · 2019Review
- Substrate transport and anion permeation proceed through distinct pathways in glutamate transporters.eLife · 2017Article
- Mode of Action of the Natural Insecticide, Decaleside Involves Sodium Pump Inhibition.PloS one · 2017Article
- Glutamate Transporters/Na(+), K(+)-ATPase Involving in the Neuroprotective Effect as a Potential Regulatory Target of Glutamate Uptake.Molecular neurobiology · 2016Review
- The modulation of erythrocyte Na(+)/K(+)-ATPase activity by curcumin.Journal of advanced research · 2015Article
- Mechanism of potassium ion uptake by the Na(+)/K(+)-ATPase.Nature communications · 2015Article
- Simulation of alcohol action upon a detailed Purkinje neuron model and a simpler surrogate model that runs >400 times faster.BMC neuroscience · 2015Article
- Cardiac glycoside activities link Na(+)/K(+) ATPase ion-transport to breast cancer cell migration via correlative SAR.ACS chemical biology · 2015Article
- Structures and characterization of digoxin- and bufalin-bound Na+,K+-ATPase compared with the ouabain-bound complex.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Model of Cation Transportation Mediated by High-Affinity Potassium Transporters (HKTs) in Higher Plants.Biological procedures online · 2015Article
- Route, mechanism, and implications of proton import during Na+/K+ exchange by native Na+/K+-ATPase pumps.The Journal of general physiology · 2014Article
- Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
P-type ATPases pump ions across membranes, generating steep electrochemical gradients that are essential for the function of all cells. Access to the ion-binding sites within the pumps alternates between the two sides of the membrane to avoid the dissipation of the gradients that would occur during simultaneous access. In Na(+),K(+)-ATPase pumps treated with the marine agent palytoxin, this strict alternation is disrupted and binding sites are sometimes simultaneously accessible from both sides of the membrane, transforming the pumps into ion channels (see, for example, refs 2, 3). Current recordings in these channels can monitor accessibility of introduced cysteine residues to water-soluble sulphydryl-specific reagents. We found previously that Na(+),K(+) pump-channels open to the extracellular surface through a deep and wide vestibule that emanates from a narrower pathway between transmembrane helices 4 and 6 (TM4 and TM6). Here we report that cysteine scans from TM1 to TM6 reveal a single unbroken cation pathway that traverses palytoxin-bound Na(+),K(+) pump-channels from one side of the membrane to the other. This pathway comprises residues from TM1, TM2, TM4 and TM6, passes through ion-binding site II, and is probably conserved in structurally and evolutionarily related P-type pumps, such as sarcoplasmic- and endoplasmic-reticulum Ca(2+)-ATPases and H(+),K(+)-ATPases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.