ArticleGenome research2008
Reconfiguration of genomic anchors upon transcriptional activation of the human major histocompatibility complex.
Article in Genome research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 37 citations in OpenAlex.
- Regulation of expression quantitative trait loci by SVA retrotransposons within the major histocompatibility complex.Experimental biology and medicine (Maywood, N.J.) · 2023Article
- Transposable elements as scaffold/matrix attachment regions: shaping organization and functions in genomes.Frontiers in molecular biosciences · 2023Article
- The 3D nuclear conformation of the major histocompatibility complex changes upon cell activation both in porcine and human macrophages.BMC molecular and cell biology · 2021Article
- Article
- Positive selection and climatic effects on MHC class II gene diversity in hares (Lepus capensis) from a steep ecological gradient.Scientific reports · 2018Article
- In vivo mapping of arabidopsis scaffold/matrix attachment regions reveals link to nucleosome-disfavoring poly(dA:dT) tracts.The Plant cell · 2014Article
- Effector bottleneck: microbial reprogramming of parasitized host cell transcription by epigenetic remodeling of chromatin structure.Frontiers in genetics · 2014Review
- GATA simple sequence repeats function as enhancer blocker boundaries.Nature communications · 2013Article
- CTCF binds to sites in the major histocompatibility complex that are rapidly reconfigured in response to interferon-gamma.Nucleic acids research · 2012Article
- Article
- Cis-regulation of microRNA expression by scaffold/matrix-attachment regions.Nucleic acids research · 2011Article
- Determination of the in vivo structural DNA loop organization in the genomic region of the rat albumin locus by means of a topological approach.DNA research : an international journal for rapid publication of reports on genes and genomes · 2010Article
- Operons.Cellular and molecular life sciences : CMLS · 2009Review
- The human Major Histocompatibility Complex as a paradigm in genomics research.Briefings in functional genomics & proteomics · 2009Review
- Silencing by nuclear matrix attachment distinguishes cell-type specificity: association with increased proliferation capacity.Nucleic acids research · 2009Article
- Differential nuclear scaffold/matrix attachment marks expressed genes.Human molecular genetics · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
Abstract
The folding of chromatin into topologically constrained loop domains is essential for genomic function. We have identified genomic anchors that define the organization of chromatin loop domains across the human major histocompatibility complex (MHC). This locus contains critical genes for immunity and is associated with more diseases than any other region of the genome. Classical MHC genes are expressed in a cell type-specific pattern and can be induced by cytokines such as interferon-gamma (IFNG). Transcriptional activation of the MHC was associated with a reconfiguration of chromatin architecture resulting from the formation of additional genomic anchors. These findings suggest that the dynamic arrangement of genomic anchors and loops plays a role in transcriptional regulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.