ArticleProceedings of the National Academy of Sciences of the United States of America2008
Modeling the effects of strain diversity and mechanisms of strain competition on the potential performance of new tuberculosis vaccines.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Mycobacterium tuberculosis mixed infections and drug resistance in sub-Saharan Africa: a systematic review.African health sciences · 2022Pooled it
- Models to predict the public health impact of vaccine resistance: A systematic review.Vaccine · 2019Pooled it
- Systematic review of mathematical models exploring the epidemiological impact of future TB vaccines.Human vaccines & immunotherapeutics · 2016Pooled it
- Vaccine-induced strain replacement: theory and real-life implications.Future microbiology · 2024Review
- Whole-Genome Sequencing Exhibits Better Diagnostic Performance than Variable-Number Tandem Repeats for Identifying Mixed Infections of Mycobacterium tuberculosis.Microbiology spectrum · 2023Article
- BCGΔBCG1419c increased memory CD8Scientific reports · 2022Article
- TheF1000Research · 2021Article
- Predicting N-Strain Coexistence from Co-colonization Interactions: Epidemiology Meets Ecology and the Replicator Equation.Bulletin of mathematical biology · 2020Article
- Interplay between competitive and cooperative interactions in a three-player pathogen system.Royal Society open science · 2020Article
- Comparative genomics shows differences in the electron transport and carbon metabolic pathways of Mycobacterium africanum relative to Mycobacterium tuberculosis and suggests an adaptation to low oxygen tension.Tuberculosis (Edinburgh, Scotland) · 2020Article
- Host contact dynamics shapes richness and dominance of pathogen strains.PLoS computational biology · 2019Article
- Identification and Evaluation of Novel Protective Antigens for the Development of a Candidate Tuberculosis Subunit Vaccine.Infection and immunity · 2018Article
- Origin, evolution, and distribution of the molecular machinery for biosynthesis of sialylated lipooligosaccharide structures in Campylobacter coli.Scientific reports · 2018Article
- HIV population-level adaptation can rapidly diminish the impact of a partially effective vaccine.Vaccine · 2018Article
- The Enigmatic PE/PPE Multigene Family of Mycobacteria and Tuberculosis Vaccination.Infection and immunity · 2017Review
- Novel vaccine potential of Rv3131, a DosR regulon-encoded putative nitroreductase, against hyper-virulent Mycobacterium tuberculosis strain K.Scientific reports · 2017Article
- Unique Regulation of the DosR Regulon in the Beijing Lineage of Mycobacterium tuberculosis.Journal of bacteriology · 2017Article
- Article
- Magnitude and sources of bias in the detection of mixed strain M. tuberculosis infection.Journal of theoretical biology · 2015Article
- Data needs for evidence-based decisions: a tuberculosis modeler's 'wish list'.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2013Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
While bacillus Calmette-Guérin vaccination plays an important role in reducing the morbidity of tuberculosis (TB) infection during childhood, new tuberculosis vaccines are necessary to disrupt the transmission of disease and improve global control of this pathogen. Growing evidence of the presence of meaningful Mycobacterium tuberculosis strain diversity, coupled with the possibility that new vaccines may differentially protect against infection or disease with circulating M. tuberculosis strains, suggest that these vaccines may have complicated effects on disease dynamics. We use a mathematical model to explore the potential effects of strain diversity on the performance of vaccines and find that vaccines offer great promise for improving tuberculosis control, but the expected benefits of mass vaccination will be eroded if strain replacement with M. tuberculosis variants that are not effectively targeted by vaccines occurs. Determining the likelihood of strain replacement will require additional knowledge of the strain specificities of current vaccine candidates, and an improved understanding of the mechanisms of strain interaction, which are responsible for maintaining the diversity of M. tuberculosis within communities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.