ArticleAmerican journal of physiology. Lung cellular and molecular physiology2008
Interleukin-1beta mediates human airway epithelial cell migration via NF-kappaB.
Article in American journal of physiology. Lung cellular and molecular physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 36 citations in OpenAlex.
- Interferon-Associated Transcriptional Responses Are Preserved in Human Asthmatic Airway Epithelial Cells During Viral Infection.International journal of molecular sciences · 2026Article
- Apical-out airway organoids as a pathophysiological model to study macrophage-mediated epithelial responses to microplastics.Materials today. Bio · 2026Article
- miR-21 Expressed by Dermal Fibroblasts Enhances Skin Wound Healing Through the Regulation of Inflammatory Cytokine Expression.Inflammation · 2024Article
- PRF Lysates Enhance the Proliferation and Migration of Oral Squamous Carcinoma Cell Lines.Dentistry journal · 2023Article
- Asthma and obesity: endotoxin another insult to add to injury?Clinical science (London, England : 1979) · 2021Review
- Long noncoding RNA TINCR is a novel regulator of human bronchial epithelial cell differentiation state.Physiological reports · 2021Article
- Altered transcriptional and chromatin responses to rhinovirus in bronchial epithelial cells from adults with asthma.Communications biology · 2020Article
- Innate IFN-lambda responses to dsRNA in the human infant airway epithelium and clinical regulatory factors during viral respiratory infections in early life.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2020Article
- Fibroblast Growth Factor 2 Augments Transforming Growth Factor Beta 1 Induced Epithelial-mesenchymal Transition in Lung Cell Culture Model.Iranian journal of allergy, asthma, and immunology · 2020Article
- Enhanced morphological transformation of human lung epithelial cells by continuous exposure to cellulose nanocrystals.Chemosphere · 2020Article
- Activity of Tracheal Cytotoxin ofFrontiers in cellular and infection microbiology · 2020Article
- Fibroblast growth factor 2 decreases bleomycin-induced pulmonary fibrosis and inhibits fibroblast collagen production and myofibroblast differentiation.The Journal of pathology · 2018Article
- Chemokine expression in the early response to injury in human airway epithelial cells.PloS one · 2018Article
- MKL1 defines the H3K4Me3 landscape for NF-κB dependent inflammatory response.Scientific reports · 2017Article
- Article
- Cigarette Smoke Modulates Repair and Innate Immunity following Injury to Airway Epithelial Cells.PloS one · 2016Article
- Peripheral blood IRF1 expression as a marker for glucocorticoid sensitivity.Pharmacogenetics and genomics · 2015Article
- Interleukin-1 beta guides the migration of cortical neurons.Journal of neuroinflammation · 2014Article
- A pro-inflammatory role for nuclear factor kappa B in childhood obstructive sleep apnea syndrome.Sleep · 2013Article
- Interleukin-1 Beta induces an inflammatory phenotype in human aortic valve interstitial cells through nuclear factor kappa Beta.The Annals of thoracic surgery · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Migration of airway epithelial cells (AEC) is a necessary component of airway mucosal repair after injury. The cytokine IL-1beta, present in airway inflammation, has protean effects on constituent cells within the mucosa, but its effects on epithelial repair are not known. We examined migration in differentiated primary human AEC grown in air-liquid interface culture for up to 3 wk and in the 16HBE14o(-) cell line. Wounds were created by mechanical abrasion and followed to closure using digital microscopy. Concurrent treatment with IL-1beta (<or=10 ng/ml) significantly accelerated migration in primary differentiated cells and in the 16HBE14o(-) cell line but did not accelerate migration in primary differentiated AEC collected from asthmatic donors. IL-1beta treatment did not augment phosphorylation of stress-activated protein kinases normally activated by mechanical injury, such as heat shock protein 27, ERK1/2, and JNK, and did not elicit phosphorylation of signal transducer and activator of transcription-3. However, introduction of a silencing RNA to block expression of the p65 component of NF-kappaB blocked IL-1beta-accelerated migration substantially. Our data demonstrate that IL-1beta accelerates migration of normal, but not asthmatic, differentiated AEC by a mechanism that requires activation of the NF-kappaB signaling complex and suggests a trophic role for this cytokine in airway epithelial repair after injury.
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Registered trials
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