ArticleJournal of bacteriology2008
Loss of RNase R induces competence development in Legionella pneumophila.
Article in Journal of bacteriology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 62 citations in OpenAlex.
- Genomic and functional dissection of natural transformation-related genes inMicrobiology spectrum · 2026Article
- Carrot and stick: how RNase R contributes to function and destruction of the translation machinery.RNA biology · 2025Review
- Exoribonuclease RNase R protects AntarcticApplied and environmental microbiology · 2023Article
- Functional activity of E. coli RNase R in the Antarctic Pseudomonas syringae Lz4W.Journal, genetic engineering & biotechnology · 2023Article
- How hydrolytic exoribonucleases impact human disease: Two sides of the same story.FEBS open bio · 2023Review
- Article
- Colonization of the Caenorhabditis elegans gut with human enteric bacterial pathogens leads to proteostasis disruption that is rescued by butyrate.PLoS pathogens · 2021Article
- Transposon Insertion Sequencing in a Clinical Isolate of Legionella pneumophila Identifies Essential Genes and Determinants of Natural Transformation.Journal of bacteriology · 2021Article
- The Bacterial Counterparts of the Eukaryotic Exosome: An Evolutionary Perspective.Methods in molecular biology (Clifton, N.J.) · 2020Review
- Article
- A Novel Cold-Adapted and Salt-Tolerant RNase R from Antarctic Sea-Ice BacteriumMolecules (Basel, Switzerland) · 2019Article
- Silently transformable: the many ways bacteria conceal their built-in capacity of genetic exchange.Current genetics · 2017Review
- Trans-translation is essential in the human pathogen Legionella pneumophila.Scientific reports · 2016Article
- Silencing of natural transformation by an RNA chaperone and a multitarget small RNA.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Legionella pneumophila strain associated with the first evidence of person-to-person transmission of Legionnaires' disease: a unique mosaic genetic backbone.Scientific reports · 2016Article
- The Membrane Protein LasM Promotes the Culturability ofFrontiers in cellular and infection microbiology · 2016Article
- Natural transformation occurs independently of the essential actin-like MreB cytoskeleton in Legionella pneumophila.Scientific reports · 2015Article
- Transcriptomic changes of Legionella pneumophila in water.BMC genomics · 2015Article
- A regulatory feedback loop between RpoS and SpoT supports the survival of Legionella pneumophila in water.Applied and environmental microbiology · 2015Article
- Genomic characterization of a large outbreak of Legionella pneumophila serogroup 1 strains in Quebec City, 2012.PloS one · 2014Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
RNase R is a processive 3'-5' exoribonuclease with a high degree of conservation in prokaryotes. Although some bacteria possess additional hydrolytic 3'-5' exoribonucleases such as RNase II, RNase R was found to be the only predicted one in the facultative intracellular pathogen Legionella pneumophila. This provided a unique opportunity to study the role of RNase R in the absence of an additional RNase with similar enzymatic activity. We investigated the role of RNase R in the biology of Legionella pneumophila under various conditions and performed gene expression profiling using microarrays. At optimal growth temperature, the loss of RNase R had no major consequence on bacterial growth and had a moderate impact on normal gene regulation. However, at a lower temperature, the loss of RNase R had a significant impact on bacterial growth and resulted in the accumulation of structured RNA degradation products. Concurrently, gene regulation was affected and specifically resulted in an increased expression of the competence regulon. Loss of the exoribonuclease activity of RNase R was sufficient to induce competence development, a genetically programmed process normally triggered as a response to environmental stimuli. The temperature-dependent expression of competence genes in the rnr mutant was found to be independent of previously identified competence regulators in Legionella pneumophila. We suggest that a physiological role of RNase R is to eliminate structured RNA molecules that are stabilized by low temperature, which in turn may affect regulatory networks, compromising adaptation to cold and thus resulting in decreased viability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.