ArticleJournal of bacteriology2008
Genetic analysis of Vibrio cholerae monolayer formation reveals a key role for DeltaPsi in the transition to permanent attachment.
Article in Journal of bacteriology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed.
- Physical communication pathways in bacteria: an extra layer to quorum sensing.Biophysical reviews · 2025Review
- Nanovibrational Stimulation ofACS nano · 2024Article
- Dual Control of Flagellar Synthesis and Exopolysaccharide Production by FlbD-FliX Class II Regulatory Proteins in Bradyrhizobium diazoefficiens.Journal of bacteriology · 2021Article
- Reciprocal c-di-GMP signaling: Incomplete flagellum biogenesis triggers c-di-GMP signaling pathways that promote biofilm formation.PLoS genetics · 2020Article
- A Skeptic's Guide to Bacterial Mechanosensing.Journal of molecular biology · 2020Review
- Repositioning of a mucolytic drug to a selective antibacterial against Vibrio cholerae.Journal of microbiology (Seoul, Korea) · 2020Article
- Targeting Type IV pili as an antivirulence strategy against invasive meningococcal disease.Nature microbiology · 2019Article
- Bacterial mechanosensing: the force will be with you, always.Journal of cell science · 2019Review
- Feedback regulation of Caulobacter crescentus holdfast synthesis by flagellum assembly via the holdfast inhibitor HfiA.Molecular microbiology · 2018Article
- Metabolic Reprogramming of Vibrio cholerae Impaired in Respiratory NADH Oxidation Is Accompanied by Increased Copper Sensitivity.Journal of bacteriology · 2018Article
- Viscous drag on the flagellum activates Bacillus subtilis entry into the K-state.Molecular microbiology · 2017Article
- Against the tide: the role of bacterial adhesion in host colonization.Biochemical Society transactions · 2016Review
- Cyclic diguanylate signaling in Gram-positive bacteria.FEMS microbiology reviews · 2016Review
- Vibrio cholerae Biofilms and Cholera Pathogenesis.PLoS neglected tropical diseases · 2016Review
- Timescales and Frequencies of Reversible and Irreversible Adhesion Events of Single Bacterial Cells.Analytical chemistry · 2015Article
- Chemical Signals and Mechanosensing in Bacterial Responses to Their Environment.PLoS pathogens · 2015Review
- Mechanosensing: a regulation sensation.Current biology : CB · 2015Article
- The acetate switch of an intestinal pathogen disrupts host insulin signaling and lipid metabolism.Cell host & microbe · 2014Article
- Mechanisms and regulation of surface interactions and biofilm formation in Agrobacterium.Frontiers in plant science · 2014Review
- A quinazoline-2,4-diamino analog suppresses Vibrio cholerae flagellar motility by interacting with motor protein PomB and induces envelope stress.Antimicrobial agents and chemotherapy · 2013Article
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Authors and funding
3 authors.
Funding
Abstract
A bacterial monolayer biofilm is a collection of cells attached to a surface but not to each other. Monolayer formation is initiated when a bacterial cell forms a transient attachment to a surface. While some transient attachments are broken, others transition into the permanent attachments that define a monolayer biofilm. In this work, we describe the results of a large-scale, microscopy-based genetic screen for Vibrio cholerae mutants that are defective in formation of a monolayer biofilm. This screen identified mutations that alter both transient and permanent attachment. Transient attachment was somewhat slower in the absence of flagellar motility. However, flagellar mutants eventually formed a robust monolayer. In contrast, in the absence of the flagellar motor, monolayer formation was severely impaired. A number of proteins that modulate the V. cholerae ion motive force were also found to affect the transition from transient to permanent attachment. Using chemicals that dissipate various components of the ion motive force, we discovered that dissipation of the membrane potential (DeltaPsi) completely blocks the transition from transient to permanent attachment. We propose that as a bacterium approaches a surface, the interaction of the flagellum with the surface leads to transient hyperpolarization of the bacterial cell membrane. This, in turn, initiates the transition to permanent attachment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.