Evidence map›Paper›PMID 18849301›Full record

ArticleAmerican journal of epidemiology2008

Validation of a hierarchical deterministic record-linkage algorithm using data from 2 different cohorts of human immunodeficiency virus-infected persons and mortality databases in Brazil.

Antonio G Pacheco, Valeria Saraceni, Suely H Tuboi, Lawrence H Moulton, Richard E Chaisson, Solange C Cavalcante, Betina Durovni, José C Faulhaber, Jonathan E Golub, Bonnie King and 2 more

Abstract readComparative StudyValidation Study
In one paragraph

Article in American journal of epidemiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Record linkage in public health datasets: a practical experience in a fast in-process analytical database.Revista brasileira de epidemiologia = Brazilian journal of epidemiology · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Observational
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Observational
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Loss to follow-up in anti-HCV-positive patients in a Brazilian regional outpatient clinic.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Antonio G PachecoPrograma de Computação Científica, Fundação Oswaldo Cruz, Avenida Brasil 4365, Manguinhos, 21045-360 Rio de Janeiro, Brazil. apacheco@fiocruz.br
Valeria Saraceni
Suely H Tuboi
Lawrence H Moulton
Richard E Chaisson
Solange C Cavalcante
Betina Durovni
José C Faulhaber
Jonathan E Golub
Bonnie King
Mauro Schechter
Lee H Harrison

Funding

CCASAnet: Caribbean, Central and South America NetworkU01AI069923 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Pedro Enrique Cahn, Jessica L Castilho · 2006 to 2026
$41.6M
Training and Research on Effectiveness of Antiretroviral TherapyD43TW001038 · FIC · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HARRISON, LEE H · 1998 to 2013
$4.7M
Shedding of HIV In Semen Despite Antiretroviral TherapyK24AI052788 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HARRISON, LEE H · 2002 to 2012
$1.4M
FIC NIH HHS 3D43 TW01038FIC NIH HHS D43 TW001038NIAID NIH HHS 1 U01 AI069923NIAID NIH HHS K24 AI052788NIAID NIH HHS U01 AI069923
6 · The paper itself

Abstract

Loss to follow-up is a major source of bias in cohorts of patients with human immunodeficiency virus (HIV) and could lead to underestimation of mortality. The authors developed a hierarchical deterministic linkage algorithm to be used primarily with cohorts of HIV-infected persons to recover vital status information for patients lost to follow-up. Data from patients known to be deceased in 2 cohorts in Rio de Janeiro, Brazil, and data from the Rio de Janeiro State mortality database for 1999-2006 were used to validate the algorithm. A fully automated procedure yielded a sensitivity of 92.9% and specificity of 100% when no information was missing. When the automated procedure was combined with clerical review, in a scenario of 5% death prevalence and 20% missing mothers' names, sensitivity reached 96.5% and specificity 100%. In a practical application, the algorithm significantly increased death rates and decreased the rate of loss to follow-up in the cohorts. The finding that 23.9% of matched records did not give HIV or acquired immunodeficiency syndrome as the cause of death reinforces the need to search all-cause mortality databases and alerts for possible underestimation of death rates. These results indicate that the algorithm is accurate enough to recover vital status information on patients lost to follow-up in cohort studies.

Indexed as

AlgorithmsDeath CertificatesMedical Record LinkageAdolescentAdultBrazilCohort StudiesDatabases, FactualFemaleHIV InfectionsHumansMaleSensitivity and SpecificitySurvival RateTuberculosis, Pulmonary

Identifiers

PMID18849301
PMCPMC2638543

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.