ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2008
Central and peripheral pathology of kuru: pathological analysis of a recent case and comparison with other forms of human prion disease.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 72 citations in OpenAlex.
- Prion diseases: Lessons from historical outbreaks and potential emerging ones.Protein science : a publication of the Protein Society · 2025Review
- Detection of prions in the urine of patients affected by sporadic Creutzfeldt-Jakob disease.Annals of clinical and translational neurology · 2023Article
- Prion strains: shining new light on old concepts.Cell and tissue research · 2023Review
- Differential Accumulation of Misfolded Prion Strains in Natural Hosts of Prion Diseases.Viruses · 2021Review
- Prevalence in Britain of abnormal prion protein in human appendices before and after exposure to the cattle BSE epizootic.Acta neuropathologica · 2020Article
- Kuru, the First Human Prion Disease.Viruses · 2019Review
- Prion Strains and Transmission Barrier Phenomena.Pathogens (Basel, Switzerland) · 2018Review
- Sporadic and Infectious Human Prion Diseases.Cold Spring Harbor perspectives in medicine · 2017Review
- Review
- Evidence for human transmission of amyloid-β pathology and cerebral amyloid angiopathy.Nature · 2015Article
- Sporadic Creutzfeldt-Jakob Disease: Prion Pathology in Medulla Oblongata-Possible Routes of Infection and Host Susceptibility.BioMed research international · 2015Article
- Prions in the urine of patients with variant Creutzfeldt-Jakob disease.The New England journal of medicine · 2014Article
- Kuru: a journey back in time from papua new Guinea to the neanderthals' extinction.Pathogens (Basel, Switzerland) · 2013Review
- Prion disease: a tale of folds and strains.Brain pathology (Zurich, Switzerland) · 2013Review
- Kuru: genes, cannibals and neuropathology.Journal of neuropathology and experimental neurology · 2012Review
- An overview of human prion diseases.Virology journal · 2011Review
- Tau, prions and Aβ: the triad of neurodegeneration.Acta neuropathologica · 2011Review
- Molecular pathology of human prion disease.Acta neuropathologica · 2011Review
- Review: contribution of transgenic models to understanding human prion disease.Neuropathology and applied neurobiology · 2010Review
- Agent strain variation in human prion disease: insights from a molecular and pathological review of the National Institutes of Health series of experimentally transmitted disease.Brain : a journal of neurology · 2010Article
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Authors and funding
12 authors at 4 institutions in 3 countries.
Funding
Abstract
While the neuropathology of kuru is well defined, there are few data concerning the distribution of disease-related prion protein in peripheral tissues. Here we report the investigation of brain and peripheral tissues from a kuru patient who died in 2003. Neuropathological findings were compared with those seen in classical (sporadic and iatrogenic) Creutzfeldt-Jakob disease (CJD) and variant CJD (vCJD). The neuropathological findings of the kuru patient showed all the stereotypical changes that define kuru, with the occurrence of prominent PrP plaques throughout the brain. Lymphoreticular tissue showed no evidence of prion colonization, suggesting that the peripheral pathogenesis of kuru is similar to that seen in classical CJD rather than vCJD. These findings now strongly suggest that the characteristic peripheral pathogenesis of vCJD is determined by prion strain type alone rather than route of infection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.