ArticleBiomaterials2009
In vivo cytokine-associated responses to biomaterials.
Article in Biomaterials, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 109 citations in OpenAlex.
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- Autologous and synthetic vascular grafts trigger different host responses in the anastomotic regions and in the perivascular adipose tissue during the early healing phase.Materials today. Bio · 2025Article
- Effects of Chemical Pretreatments of Wood Cellulose Nanofibrils on Protein Adsorption and Biological Outcomes.ACS applied materials & interfaces · 2025Article
- Unraveling and Harnessing the Immune Response at the Cell-Biomaterial Interface for Tissue Engineering Purposes.Advanced healthcare materials · 2024Review
- A biological study establishing the endotoxin limit for osteoblast and adipocyte differentiation of human mesenchymal stem cells.Regenerative therapy · 2018Article
- A biological study establishing the endotoxin limit for in vitro proliferation of human mesenchymal stem cells.Regenerative therapy · 2017Article
- Backbone-Degradable Polymers Prepared by Chemical Vapor Deposition.Angewandte Chemie (International ed. in English) · 2017Article
- Neuroadhesive L1 coating attenuates acute microglial attachment to neural electrodes as revealed by live two-photon microscopy.Biomaterials · 2017Article
- Cytokine induction of sol-gel-derived TiOInternational journal of nanomedicine · 2017Article
- Environmental Factors Impacting Bone-Relevant Chemokines.Frontiers in endocrinology · 2017Article
- Tissue integration and inflammatory reaction in full-thickness abdominal wall repair using an innovative composite mesh.Hernia : the journal of hernias and abdominal wall surgery · 2016Article
- Engineering macrophages to control the inflammatory response and angiogenesis.Experimental cell research · 2015Article
- Macrophage-mediated osteogenesis activation in co-culture with osteoblast on calcium silicate cement.Journal of materials science. Materials in medicine · 2015Article
- The Effect of Interferon-γ and Zoledronate Treatment on Alpha-Tricalcium Phosphate/Collagen Sponge-Mediated Bone-Tissue Engineering.International journal of molecular sciences · 2015Article
- Extended culture of macrophages from different sources and maturation results in a common M2 phenotype.Journal of biomedical materials research. Part A · 2015Article
- Bioanalytical chemistry of cytokines--a review.Analytica chimica acta · 2015Review
- Effects of mesenchymal stem cell and fibroblast coating on immunogenic potential of prosthetic meshes in vitro.Surgical endoscopy · 2014Article
- Long-acting atypical antipsychotics: characterization of the local tissue response.Pharmaceutical research · 2014Article
- Microdialysis sampling techniques applied to studies of the foreign body reaction.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · 2014Review
- Intracellular signaling mechanisms associated with CD47 modified surfaces.Biomaterials · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Cytokines, chemokines, and growth factors were analyzed periodically over eight weeks from the wound exudate fluid surrounding biomaterials implanted subcutaneously within stainless steel mesh cages. TNF-alpha, MCP-1, MIP-1alpha, IL-2, IL-6, IL-1beta, VEGF, IL-4, and IL-10 were measured from exudate samples collected from cages containing specimens of polyethylene (PE), polyurethane (PU), or organotin polyvinyl chloride (ot-PVC). Empty cages served as negative controls, and lipopolysaccharide (LPS) served as a positive control. Cytokine, chemokine, and growth factor concentrations decreased from the time of implantation to eight weeks post-implantation, and there was an overall increase in cytokine, chemokine, and growth factor production for material-containing cages compared to empty cages. However, cytokine production was only modestly affected by the different surface chemistries of the three implanted polymeric materials.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.