ArticleGenomics2009
Adaptive history of single copy genes highly expressed in the term human placenta.
Article in Genomics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Extensive load of somatic CNVs in the human placenta.Scientific reports · 2015Trial
- Specific expression and blood kinetics for relaxin 2, lipocalin 2, and tissue factor pathway inhibitor 2 at the canine placenta and pregnant bloods.The Journal of veterinary medical science · 2024Article
- Repetitive DNA sequence detection and its role in the human genome.Communications biology · 2023Review
- Article
- Organoids as Novel Models for Embryo Implantation Study.Reproductive sciences (Thousand Oaks, Calif.) · 2021Review
- The Genomes of the Livebearing Fish Species Poeciliopsis retropinna and Poeciliopsis turrubarensis Reflect Their Different Reproductive Strategies.Molecular biology and evolution · 2020Article
- The genome of the live-bearing fish Heterandria formosa implicates a role of conserved vertebrate genes in the evolution of placental fish.BMC evolutionary biology · 2019Article
- Revisiting avian 'missing' genes from de novo assembled transcripts.BMC genomics · 2019Article
- Hemochorial placentation: development, function, and adaptations.Biology of reproduction · 2018Review
- Ancestral resurrection of anthropoid estrogen receptor β demonstrates functional consequences of positive selection.Molecular phylogenetics and evolution · 2017Article
- Placental origins of adverse pregnancy outcomes: potential molecular targets: an Executive Workshop Summary of the Eunice Kennedy Shriver National Institute of Child Health and Human Development.American journal of obstetrics and gynecology · 2016Article
- The evolution of embryo implantation.The International journal of developmental biology · 2014Review
- Integrating de novo transcriptome assembly and cloning to obtain chicken Ovocleidin-17 full-length cDNA.PloS one · 2014Article
- Evolutionary perspectives into placental biology and disease.Applied & translational genomics · 2013Review
- From PPROM to caul: The evolution of membrane rupture in mammals.Applied & translational genomics · 2013Review
- Retroviruses facilitate the rapid evolution of the mammalian placenta.BioEssays : news and reviews in molecular, cellular and developmental biology · 2013Article
- Endogenous retroviruses function as species-specific enhancer elements in the placenta.Nature genetics · 2013Article
- Rat placentation: an experimental model for investigating the hemochorial maternal-fetal interface.Placenta · 2012Review
- Regulatory pathways controlling the endovascular invasive trophoblast cell lineage.The Journal of reproduction and development · 2012Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
The chorioallantoic placenta is a shared derived feature of "placental" mammals essential for the success of eutherian reproduction. Identifying the genes involved in the emergence of the placenta may provide clues for understanding the biology of this organ. Here we identify among 4960 single copy genes in mammals, 222 that show high expression levels in human placentas at term. Further, we present evidence that 94 of these 222 genes evolved adaptively during human evolutionary history since the time of the last common ancestor of eutherian mammals. Remarkably, the majority of positive selection occurred on the eutherian stem lineage suggesting that ancient adaptations have been retained in the human placenta. Of these positively selected genes, 28 have been shown to play a role in human pregnancy and placental biology, and at least 26 have important pregnancy-related phenotypes in mice. Adaptations in genes highly expressed in human placenta are attractive candidates for functional and clinical studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.