Evidence map›Paper›PMID 18848520›Full record

ArticleBiochemical and biophysical research communications2008

SNM1A acts downstream of ATM to promote the G1 cell cycle checkpoint.

Shamima Akhter, Randy J Legerski

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemical and biophysical research communications, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Structure and Function of SNM1 Family Nucleases.Advances in experimental medicine and biology · 2023
    Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. The multifunctional SNM1 gene family: not just nucleases.Future oncology (London, England) · 2010
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Shamima AkhterDepartment of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Randy J Legerski
The University of Texas MD Anderson Cancer Center · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
Recognition and processing of complex lesions by components from multiple DNAP01CA097175 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI NAIRN, RODNEY S · 2004 to 2014
$15.3M
ISOLATION AND ANALYSIS OF HUMAN DNA REPAIR GENESR01CA052461 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI LEGERSKI, RANDY J · 1992 to 2006
$1.6M
NCI NIH HHS CA052461NCI NIH HHS CA097175NCI NIH HHS CA16672NCI NIH HHS P01 CA097175NCI NIH HHS P30 CA016672NCI NIH HHS R01 CA052461
6 · The paper itself

Abstract

We have shown previously that SNM1A colocalizes with 53BP1 at sites of double-strand breaks (DSBs) induced by IR, and that these proteins interact with or without DNA damage. However, the role of SNM1A in the DNA damage response has not been elucidated. Here, we show that SNM1A is required for an efficient G1 checkpoint arrest after IR exposure. Interestingly, the localization of SNM1A to sites of DSBs does not require either 53BP1 or H2AX, nor does the localization of 53BP1 require SNM1A. However, the localization of SNM1A does require ATM. Furthermore, SNM1A is shown to be a phosphorylation substrate of ATM in vitro, and to interact with ATM in vivo particularly after exposure of cells to IR. In addition, in the absence of SNM1A the activation of the downstream ATM target p53 is reduced. These findings suggest that SNM1A acts with ATM to promote the G1 cell cycle checkpoint.

Indexed as

G1 PhaseAtaxia Telangiectasia Mutated ProteinsCell Cycle ProteinsDNA-Binding ProteinsDNA Breaks, Double-StrandedDNA Repair EnzymesExodeoxyribonucleasesHistonesHumansIntracellular Signaling Peptides and ProteinsNuclear ProteinsPhosphorylationProtein Serine-Threonine KinasesRadiation, IonizingTumor Suppressor p53-Binding Protein 1Tumor Suppressor ProteinsAtaxia Telangiectasia Mutated ProteinsATM protein, humanCell Cycle ProteinsDCLRE1B protein, humanDNA-Binding ProteinsDNA Repair EnzymesExodeoxyribonucleasesH2AX protein, humanHistonesIntracellular Signaling Peptides and ProteinsNuclear ProteinsProtein Serine-Threonine KinasesTP53BP1 protein, humanTumor Suppressor p53-Binding Protein 1Tumor Suppressor Proteins

Identifiers

PMID18848520
PMCPMC2586765
OpenAlexW2062028873

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.