ArticleJournal of the American Society for Mass Spectrometry2008
Probing peptide fragment ion structures by combining sustained off-resonance collision-induced dissociation and gas-phase H/D exchange (SORI-HDX) in Fourier transform ion-cyclotron resonance (FT-ICR) instruments.
Article in Journal of the American Society for Mass Spectrometry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 35 citations in OpenAlex.
- The Role of Ultrahigh Resolution Fourier Transform Mass Spectrometry (FT-MS) in Astrobiology-Related Research: Analysis of Meteorites and Tholins.International journal of molecular sciences · 2016Article
- Proton Mobility in b₂ Ion Formation and Fragmentation Reactions of Histidine-Containing Peptides.Journal of the American Society for Mass Spectrometry · 2016Article
- Formation of a(1) ions directly from oxazolone b(2) ions: an energy-resolved and computational study.Journal of the American Society for Mass Spectrometry · 2015Article
- Loss of internal backbone carbonyls: additional evidence for sequence-scrambling in collision-induced dissociation of y-type ions.Journal of the American Society for Mass Spectrometry · 2014Article
- Evidence for sequence scrambling and divergent H/D exchange reactions of doubly-charged isobaric b-type fragment ions.Journal of the American Society for Mass Spectrometry · 2014Article
- Evidence for sequence scrambling in collision-induced dissociation of y-type fragment ions.Journal of the American Society for Mass Spectrometry · 2013Article
- Non-direct sequence ions in the tandem mass spectrometry of protonated peptide amides--an energy-resolved study.Journal of the American Society for Mass Spectrometry · 2013Article
- Combined use of post-ion mobility/collision-induced dissociation and chemometrics for b fragment ion analysis.Journal of the American Society for Mass Spectrometry · 2013Article
- Using gas-phase guest-host chemistry to probe the structures of b ions of peptides.Journal of the American Society for Mass Spectrometry · 2012Article
- The influence glutamic acid in protonated bInternational journal of mass spectrometry · 2012Article
- Relative stability of peptide sequence ions generated by tandem mass spectrometry.Journal of the American Society for Mass Spectrometry · 2012Article
- Separation and identification of structural isomers by quadrupole collision-induced dissociation-hydrogen/deuterium exchange-infrared multiphoton dissociation (QCID-HDX-IRMPD).Journal of the American Society for Mass Spectrometry · 2010Article
- Oxazolone versus macrocycle structures for Leu-enkephalin b2-b4: insights from infrared multiple-photon dissociation spectroscopy and gas-phase hydrogen/deuterium exchange.Journal of the American Society for Mass Spectrometry · 2010Article
- Evidence of diketopiperazine and oxazolone structures for HA b2+ ion.Journal of the American Chemical Society · 2009Article
- What is the structure of b(2) ions generated from doubly protonated tryptic peptides?Journal of the American Society for Mass Spectrometry · 2009Article
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1 author at 1 institution in 1 country.
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Abstract
The usefulness of gas-phase H/D exchange is demonstrated to probe heterogeneous fragment and parent ion populations. Singly and multiply protonated peptides/proteins were fragmented by using sustained off-resonance irradiation collision-induced dissociation (SORI-CID). The fragments and the surviving precursor ions then all undergo H/D exchange in the gas-phase with either D(2)O or CD(3)OD under the same experimental conditions. Usually, 10 to 60 s of reaction time is adequate to monitor characteristic differences in the H/D exchange kinetic rates. These differences are then correlated to isomeric ion structures. The SORI-HDX method can be used to rapidly test fragment ion structures and provides useful insights into peptide fragmentation mechanisms.
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