ArticleMalaria journal2008
Complement factors C1q, C3 and C5 in brain and serum of mice with cerebral malaria.
Article in Malaria journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
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- The Defensive Interactions of Prominent Infectious Protozoan Parasites: The Host's Complement System.Biomolecules · 2022Review
- Interaction Between the Complement System and Infectious Agents - A Potential Mechanistic Link to Neurodegeneration and Dementia.Frontiers in cellular neuroscience · 2021Review
- Cell specificity dictates similarities in gene expression in multiple sclerosis, Parkinson's disease, and Alzheimer's disease.PloS one · 2017Article
- Autoimmune diseases, gastrointestinal disorders and the microbiome in schizophrenia: more than a gut feeling.Schizophrenia research · 2016Review
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- Innate immunity and neuroinflammation.Mediators of inflammation · 2013Review
- Anti-malarial effect of gum arabic.Malaria journal · 2011Article
- Nitric oxide protection against murine cerebral malaria is associated with improved cerebral microcirculatory physiology.The Journal of infectious diseases · 2011Article
- Molecular correlates of experimental cerebral malaria detectable in whole blood.Infection and immunity · 2011Article
- Complement gene expression and regulation in mouse retina and retinal pigment epithelium/choroid.Molecular vision · 2011Article
- A rapid murine coma and behavior scale for quantitative assessment of murine cerebral malaria.PloS one · 2010Article
- Beneficial effect of aurothiomalate on murine malaria.Malaria journal · 2010Article
- Azathioprine favourably influences the course of malaria.Malaria journal · 2009Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe patho-mechanisms leading to brain damage due to cerebral malaria (CM) are yet not fully understood. Immune-mediated and ischaemic mechanisms have been implicated. The role of complement factors C1q, C3 and C5 for the pathogenesis of CM were investigated in this study.
methodsC57BL/6J mice were infected with Plasmodium berghei ANKA blood stages. The clinical severity of the disease was assessed by a battery of 40 standardized tests for evaluating neurological functions in mice. Brain homogenates and sera of mice with CM, infected animals without CM and non-infected control animals were analyzed for C1q, C3 and C5 up-regulation by Western blotting.
resultsDensitometric analysis of Western blots of brain homogenates yielded statistically significant differences in the levels of C1q and C5 in the analyzed groups. Correlation analysis showed a statistically significant association of C1q and C5 levels with the clinical severity of the disease. More severely affected animals showed higher levels of C1q and C5. No differences in complement levels were observed between frontal and caudal parts of the brain. Densitometric analysis of Western blot of sera yielded statistically lower levels of C1q in infected animals without CM compared to animals of the control group.
conclusionThe current study provides direct evidence for up-regulation of complement factors C1q and C5 in the brains of animals with CM. Local complement up-regulation is a possible mechanism for brain damage in experimental cerebral malaria.
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