ArticleBMC developmental biology2008
Varicose: a MAGUK required for the maturation and function of Drosophila septate junctions.
Article in BMC developmental biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
- A role for Myo-II zipper and spaghetti squash in Gliotactin-dependent Drosophila melanogaster wing hair planar cell polarity.PloS one · 2025Article
- Septate junction proteins are required for cell shape changes, actomyosin reorganization and cell adhesion during dorsal closure inFrontiers in cell and developmental biology · 2022Article
- Expanding the Junction: New Insights into Non-Occluding Roles for Septate Junction Proteins during Development.Journal of developmental biology · 2021Review
- Neuronal immunoglobulin superfamily cell adhesion molecules in epithelial morphogenesis: insights fromPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Article
- Varicose and cheerio collaborate with pebble to mediate semaphorin-1a reverse signaling inProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Immunohistochemical study of the membrane skeletal protein, membrane protein palmitoylated 6 (MPP6), in the mouse small intestine.Histochemistry and cell biology · 2016Article
- The novel Smad protein Expansion regulates the receptor tyrosine kinase pathway to control Drosophila tracheal tube size.Developmental biology · 2014Article
- Novel mechanisms of tube-size regulation revealed by the Drosophila trachea.Cell and tissue research · 2013Review
- Control of tissue morphology by Fasciclin III-mediated intercellular adhesion.Development (Cambridge, England) · 2013Article
- dusky-like is required to maintain the integrity and planar cell polarity of hairs during the development of the Drosophila wing.Developmental biology · 2013Article
- Focal defects in single-celled tubes mutant for Cerebral cavernous malformation 3, GCKIII, or NSF2.Developmental cell · 2013Article
- The frizzled/stan pathway and planar cell polarity in the Drosophila wing.Current topics in developmental biology · 2012Review
- Essential function of protein 4.1G in targeting of membrane protein palmitoylated 6 into Schmidt-Lanterman incisures in myelinated nerves.Molecular and cellular biology · 2012Article
- Duox, Flotillin-2, and Src42A are required to activate or delimit the spread of the transcriptional response to epidermal wounds in Drosophila.PLoS genetics · 2011Article
- A perisynaptic ménage à trois between Dlg, DLin-7, and Metro controls proper organization of Drosophila synaptic junctions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- The functional organisation of glia in the adult brain of Drosophila and other insects.Progress in neurobiology · 2010Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundScaffolding proteins belonging to the membrane associated guanylate kinase (MAGUK) superfamily function as adapters linking cytoplasmic and cell surface proteins to the cytoskeleton to regulate cell-cell adhesion, cell-cell communication and signal transduction. We characterize here a Drosophila MAGUK member, Varicose (Vari), the homologue of vertebrate scaffolding protein PALS2.
resultsVaricose localizes to pleated septate junctions (pSJs) of all embryonic, ectodermally-derived epithelia and peripheral glia. In vari mutants, essential SJ proteins NeurexinIV and FasciclinIII are mislocalized basally and epithelia develop a leaky paracellular seal. In addition, vari mutants display irregular tracheal tube diameters and have reduced lumenal protein accumulation, suggesting involvement in tracheal morphogenesis. We found that Vari is distributed in the cytoplasm of the optic lobe neuroepithelium, as well as in a subset of neuroblasts and differentiated neurons of the nervous system. We reduced vari function during the development of adult epithelia with a partial rescue, RNA interference and generation of genetically mosaic tissue. All three approaches demonstrate that vari is required for the patterning and morphogenesis of adult epithelial hairs and bristles.
conclusionVaricose is involved in scaffold assembly at the SJ and has a role in patterning and morphogenesis of adult epithelia.
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