ArticleInfectious agents and cancer2008
Molecular and phylogenetic analysis of HIV-1 variants circulating in Italy.
Article in Infectious agents and cancer, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Molecular epidemiology of HIV-1 infection in immigrant population in northern Italy.Epidemiology and infection · 2020Article
- Expanding HIV-1 subtype B transmission networks among men who have sex with men in Poland.PloS one · 2017Article
- An epidemiological investigation to reconstruct a probable human immunodeficiency virus-1 transmission network: a case report.Journal of medical case reports · 2015Article
- Article
- HIV-1 subtype D infections among Caucasians from Northwestern Poland--phylogenetic and clinical analysis.PloS one · 2012Article
Corrections and comments
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Authors and funding
11 authors.
Funding
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Abstract
objectiveThe continuous identification of HIV-1 non-B subtypes and recombinant forms in Italy indicates the need of constant molecular epidemiology survey of genetic forms circulating and transmitted in the resident population.
methodsThe distribution of HIV-1 subtypes has been evaluated in 25 seropositive individuals residing in Italy, most of whom were infected through a sexual route during the 1995-2005 period. Each sample has been characterized by detailed molecular and phylogenetic analyses.
results18 of the 25 samples were positive at HIV-1 PCR amplification. Three samples showed a nucleotide divergence compatible with a non-B subtype classification. The phylogenetic analysis, performed on both HIV-1 env and gag regions, confirms the molecular sub-typing prediction, given that 1 sample falls into the C subtype and 2 into the G subtype. The B subtype isolates show high levels of intra-subtype nucleotide divergence, compatible with a long-lasting epidemic and a progressive HIV-1 molecular diversification.
conclusionThe Italian HIV-1 epidemic is still mostly attributable to the B subtype, regardless the transmission route, which shows an increasing nucleotide heterogeneity. Heterosexual transmission and the interracial blending, however, are slowly introducing novel HIV-1 subtypes. Therefore, a molecular monitoring is needed to follow the constant evolution of the HIV-1 epidemic.
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