ArticleBMC physiology2008
Butyrate ingestion improves hepatic glycogen storage in the re-fed rat.
Article in BMC physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Can probiotic, prebiotic, and synbiotic supplementation modulate the gut-liver axis in type 2 diabetes? A narrative and systematic review of clinical trials.Frontiers in nutrition · 2022Pooled it
- The Role of Gut Microbiome-Derived Short-Chain Fatty Acid Butyrate in Hepatobiliary Diseases.The American journal of pathology · 2023Review
- A Mix of Dietary Fibres Changes Interorgan Nutrients Exchanges and Muscle-Adipose Energy Handling in Overfed Mini-Pigs.Nutrients · 2021Article
- Coronavirus disease-2019 and the intestinal tract: An overview.World journal of gastroenterology · 2021Review
- Gut Microbiota and Gestational Diabetes Mellitus: A Review of Host-Gut Microbiota Interactions and Their Therapeutic Potential.Frontiers in cellular and infection microbiology · 2020Review
- Novel carbohydrate binding modules in the surface anchored α-amylase of Eubacterium rectale provide a molecular rationale for the range of starches used by this organism in the human gut.Molecular microbiology · 2018Article
- c-Fos induction by gut hormones and extracellular ATP in osteoblastic-like cell lines.Purinergic signalling · 2016Article
- Short- and medium-chain fatty acids in energy metabolism: the cellular perspective.Journal of lipid research · 2016Review
- Mechanisms Linking the Gut Microbiome and Glucose Metabolism.The Journal of clinical endocrinology and metabolism · 2016Review
- Article
- High consumption of pulses is associated with lower risk of abnormal glucose metabolism in women in Mauritius.Diabetic medicine : a journal of the British Diabetic Association · 2015Article
- Article
- A metabolic link between mitochondrial ATP synthesis and liver glycogen metabolism: NMR study in rats re-fed with butyrate and/or glucose.Nutrition & metabolism · 2011Article
- AMPK as Target for Intervention in Childhood and Adolescent Obesity.Journal of obesity · 2011Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundButyrate naturally produced by intestinal fiber fermentation is the main nutrient for colonocytes, but the metabolic effect of the fraction reaching the liver is not totally known. After glycogen hepatic depletion in the 48-hour fasting rat, we monitored the effect of (butyrate 1.90 mg + glucose 14.0 mg)/g body weight versus isocaloric (glucose 18.2 mg/g) or isoglucidic (glucose 14.0 mg/g) control force-feeding on in vivo changes in hepatic glycogen and ATP contents evaluated ex vivo by NMR in the isolated and perfused liver.
resultsThe change in glycogen was biphasic with (i) an initial linear period where presence of butyrate in the diet increased (P = 0.05) the net synthesis rate (0.20 +/- 0.01 micromol/min.g(-1) liver wet weight, n = 15) versus glucose 14.0 mg/g only (0.16 +/- 0.01 micromol/min.g(-1) liver ww, n = 14), and (ii) a plateau of glycogen store followed by a depletion. Butyrate delayed the establishment of the equilibrium between glycogenosynthetic and glycogenolytic fluxes from the 6th to 8th hour post-feeding. The maximal glycogen content was then 97.27 +/- 10.59 micromol/g liver ww (n = 7) at the 8th hour, which was significantly higher than with the isocaloric control diet (64.34 +/- 8.49 micromol/g, n = 12, P = 0.03) and the isoglucidic control one (49.11 +/- 6.35 micromol/g liver ww, n = 6, P = 0.003). After butyrate ingestion, ATP content increased from 0.95 +/- 0.29 to a plateau of 2.14 +/- 0.23 micromol/g liver ww at the 8th hour post-feeding (n = 8) [P = 0.04 versus isoglucidic control diet (1.45 +/- 0.19 micromol/g, n = 8) but was not different from the isocaloric control diet (1.70 +/- 0.18 micromol/g, n = 12)].
conclusionThe main hepatic effect of butyrate is a sparing effect on glycogen storage explained (i) by competition between butyrate and glucose oxidation, glucose being preferentially directed to glycogenosynthesis during the post-prandial state; and (ii) by a likely reduced glycogenolysis from the newly synthesized glycogen. This first demonstration of the improvement of liver glycogen storage by acute butyrate supply may be an important contribution to explaining the beneficial effects on glucose homeostasis of nutritional supply increasing butyrate amount such as fiber diets.
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