ArticlePLoS biology2008
A regulatory code for neuron-specific odor receptor expression.
Article in PLoS biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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39 citing papers in PubMed, 71 citations in OpenAlex.
- New dimensions in the molecular genetics of insect chemoreception.Trends in genetics : TIG · 2025Review
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- Copy number changes in co-expressed odorant receptor genes enable selection for sensory differences in drosophilid species.Nature ecology & evolution · 2022Article
- Non-canonical odor coding in the mosquito.Cell · 2022Article
- Chemoreceptor co-expression ineLife · 2022Article
- A combinatorial cis-regulatory logic restricts color-sensing Rhodopsins to specific photoreceptor subsets in Drosophila.PLoS genetics · 2021Article
- Stress and odorant receptor feedback during a critical period after hatching regulates olfactory sensory neuron differentiation in Drosophila.PLoS biology · 2021Article
- Olfactory Receptor Gene Regulation in Insects: Multiple Mechanisms for Singular Expression.Frontiers in neuroscience · 2021Review
- Expansions of chemosensory gene orthologs among selected tsetse fly species and their expressions in Glossina morsitans morsitans tsetse fly.PLoS neglected tropical diseases · 2020Article
- Strength in diversity: functional diversity among olfactory neurons of the same type.Journal of bioenergetics and biomembranes · 2019Review
- Article
- Mechanisms controlling diversification of olfactory sensory neuron classes.Cellular and molecular life sciences : CMLS · 2017Review
- Organization and function ofeLife · 2016Article
- Article
- A Functionally Conserved Gene Regulatory Network Module Governing Olfactory Neuron Diversity.PLoS genetics · 2016Article
- Drosophila Chemoreceptors: A Molecular Interface Between the Chemical World and the Brain.Trends in genetics : TIG · 2015Review
- Drosophila Avoids Parasitoids by Sensing Their Semiochemicals via a Dedicated Olfactory Circuit.PLoS biology · 2015Article
- Brain composition in Godyris zavaleta, a diurnal butterfly, Reflects an increased reliance on olfactory information.The Journal of comparative neurology · 2015Article
- Causes and consequences of genetic background effects illuminated by integrative genomic analysis.Genetics · 2014Article
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3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Olfactory receptor neurons (ORNs) must select-from a large repertoire-which odor receptors to express. In Drosophila, most ORNs express one of 60 Or genes, and most Or genes are expressed in a single ORN class in a process that produces a stereotyped receptor-to-neuron map. The construction of this map poses a problem of receptor gene regulation that is remarkable in its dimension and about which little is known. By using a phylogenetic approach and the genome sequences of 12 Drosophila species, we systematically identified regulatory elements that are evolutionarily conserved and specific for individual Or genes of the maxillary palp. Genetic analysis of these elements supports a model in which each receptor gene contains a zip code, consisting of elements that act positively to promote expression in a subset of ORN classes, and elements that restrict expression to a single ORN class. We identified a transcription factor, Scalloped, that mediates repression. Some elements are used in other chemosensory organs, and some are conserved upstream of axon-guidance genes. Surprisingly, the odor response spectra and organization of maxillary palp ORNs have been extremely well-conserved for tens of millions of years, even though the amino acid sequences of the receptors are not highly conserved. These results, taken together, define the logic by which individual ORNs in the maxillary palp select which odor receptors to express.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.