ArticlePediatric pulmonology2008
Measurement of maximal inspiratory pressure in ventilated children.
Article in Pediatric pulmonology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 43 citations in OpenAlex.
- Inspiratory muscle conditioning exercise and diaphragm gene therapy in Pompe disease: Clinical evidence of respiratory plasticity.Experimental neurology · 2017Trial
- Phase I/II trial of adeno-associated virus-mediated alpha-glucosidase gene therapy to the diaphragm for chronic respiratory failure in Pompe disease: initial safety and ventilatory outcomes.Human gene therapy · 2013Trial
- Evolution of inspiratory muscle function in children during mechanical ventilation.Critical care (London, England) · 2021Observational
- Respiratory Muscle Strength in Healthy Indian Children of Age 7-17 Years: A Cross-Sectional Study.International journal of general medicine · 2021Article
- A Phase II randomized controlled trial for lung and diaphragm protective ventilation (Real-time Effort Driven VENTilator management).Contemporary clinical trials · 2020Article
- The predictive value of diaphragm ultrasound for weaning outcomes in critically ill children.BMC pulmonary medicine · 2019Article
- [Research advances in validity of predictors for extubation outcome in children receiving invasive mechanical ventilation].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2019Review
- Risk Factors for Pediatric Extubation Failure: The Importance of Respiratory Muscle Strength.Critical care medicine · 2017Article
- Reference Values for Inspiratory Muscle Endurance in Healthy Children and Adolescents.PloS one · 2017Observational
- Parasternal intercostal electromyography: a novel tool to assess respiratory load in children.Pediatric research · 2016Article
- Respiratory motor function in individuals with centronuclear myopathies.Muscle & nerve · 2016Article
- An Official American Thoracic Society/European Respiratory Society Workshop Report: Evaluation of Respiratory Mechanics and Function in the Pediatric and Neonatal Intensive Care Units.Annals of the American Thoracic Society · 2016Review
- Respiratory assessment in centronuclear myopathies.Muscle & nerve · 2014Review
- Intrinsic transient tracheal occlusion training and myogenic remodeling of rodent parasternal intercostal fibers.Journal of rehabilitation research and development · 2014Article
- Inspiratory muscle strength training in infants with congenital heart disease and prolonged mechanical ventilation: a case report.Physical therapy · 2013Article
- Chronic intrinsic transient tracheal occlusion elicits diaphragmatic muscle fiber remodeling in conscious rodents.PloS one · 2012Article
- Comment on "Adult ICU ventilators to provide neonatal ventilation: a lung simulator study".Intensive care medicine · 2009Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Maximal inspiratory pressure (PIMAX), the maximum negative pressure generated during temporary occlusion of the airway, is commonly used to measure inspiratory muscle strength in mechanically ventilated infants and children. There are, however, no guidelines as to how the PIMAX measurement should be made. We compared the maximum inspiratory pressure generated during airway occlusion (PIMAX(OCC)) to that when a unidirectional valve (PIMAX(UNI)), which allowed expiration, but not inspiration was used. Twenty-two mechanically ventilated children (mean (SD) age 4.8 (4.5) years) were studied. Three sets of end expiratory occlusions were performed for each method in random order. The expired volume during PIMAX(UNI) was assessed and related to the functional residual capacity (FRC) measured using a helium dilution technique.The mean (SD) PIMAX(UNI) (45.5 (15.2) cmH(2)O) was significantly greater than mean (SD) PIMAX(OCC) (30.9 (9.0) cmH(2)O) (P < 0.0001). The mean (SD) expired volume during PIMAX(UNI), was 98 ml (62.3), a mean reduction in FRC of 33.1% (SD 13.9). There were no significant differences between techniques in the baseline respiratory drive, the number of efforts required and the time to reach PIMAX. Regardless of technique, PIMAX was reached in 10 inspiratory efforts or 15 sec of airway occlusion.A unidirectional valve allowing expiration, but not inspiration yields greater PIMAX values in children. Occlusions should be maintained for 12 sec or eight breaths (99% CI of mean).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.