ArticlePediatric nephrology (Berlin, Germany)2009
Membranous glomerulonephritis: treatment response and outcome in children.
Article in Pediatric nephrology (Berlin, Germany), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 41 citations in OpenAlex.
- Risk stratification guided treatment and outcomes of pediatric membranous nephropathy.Pediatric nephrology (Berlin, Germany) · 2026Observational
- Cyclosporine and fedratinib combination therapy via modulating Th17/Treg balance in Rat model of membranous glomerulonephritis.Biochemistry and biophysics reports · 2024Article
- How to Choose the Right Treatment for Membranous Nephropathy.Medicina (Kaunas, Lithuania) · 2023Review
- Clinical and Histopathologic Characteristics of Pediatric Patients With Primary Membranous Nephropathy.Kidney international reports · 2023Article
- Pediatric membranous nephropathy: In the novel antigens era.Frontiers in immunology · 2022Review
- Identification of a Locus on the X Chromosome Linked to Familial Membranous Nephropathy.Kidney international reports · 2021Article
- Primary membranous nephropathy in children and adolescents: a single-centre report from South Asia.Pediatric nephrology (Berlin, Germany) · 2021Article
- Membranous nephropathy: diagnosis, treatment, and monitoring in the post-PLA2R era.Pediatric nephrology (Berlin, Germany) · 2021Review
- Clinical and Pathophysiological Insights Into Immunological Mediated Glomerular Diseases in Childhood.Frontiers in pediatrics · 2020Review
- Idiopathic membranous nephropathy in children treated with rituximab: report of two cases.Pediatric nephrology (Berlin, Germany) · 2018Article
- Children with Steroid-Resistant Nephrotic Syndrome: A Single -Center Experience.Materia socio-medica · 2018Article
- Membranous nephropathy: not just a disease for adults.Pediatric nephrology (Berlin, Germany) · 2015Review
- Membranous nephropathy associated with angiomatoid fibrous histiocytoma in a pediatric patient.Pediatric nephrology (Berlin, Germany) · 2014Article
- Phospholipase A2 receptor staining in pediatric idiopathic membranous glomerulopathy.Pediatric nephrology (Berlin, Germany) · 2013Article
- Chapter 7: Idiopathic membranous nephropathy.Kidney international supplements · 2012Article
- Membranous nephropathy in children: clinical presentation and therapeutic approach.Pediatric nephrology (Berlin, Germany) · 2010Review
- The Clinical Profile and Long-Term Outcome of Children with Membranous Nephropathy, and the Evaluation of Anti-Phospholipase A2 Receptor Antibody Immunohistochemistry in Kidney Biopsy.Indian journal of nephrologyArticle
- Difficult Renal Pathological Classification in a Case of Pediatric Nephrotic Syndrome.Case reports in nephrology and dialysisArticle
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to characterize clinical features, treatment response, and outcome of idiopathic membranous glomerulonephritis (MGN) in a single-center cohort of children. A retrospective review of biopsy-proven idiopathic MGN in 12 children (mean age 11.9 years) was undertaken. Presentation was nephrotic syndrome (NS) (75%), hematuria/proteinuria (17%), and asymptomatic proteinuria (8%). Ten patients (83%) with NS and nephrotic range proteinuria (NRP) were treated with prednisone, and two patients with non-NRP were not treated with immunosuppressive medications. Steroid response in the treated patients was complete (10%), partial (40%), and absent (50%), respectively. Oral cyclophosphamide was used in seven patients of whom five were steroid resistant, one was steroid dependent, and one was partially responsive. At the mean follow up of 27 months, outcome parameters included an estimated glomerular filtration rate of 128 cc/min per 1.73 m(2), albumin of 4.2 gm/dL, and a urine protein/creatinine ratio of 0.87 [median 0.16 (range 0.02-6.52)]. Remission was complete in 75% of the patients and partial in 17%. One patient (8%) with chronic kidney disease (stage 2) was unresponsive to therapy. Complete remission was significantly associated with the absence of chronic histological changes (p = 0.03). In conclusion, children with NS and/or NRP associated with MGN appear to have a good prognosis when treated with a combination of corticosteroids and cyclophosphamide.
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