ArticleJournal of cancer research and clinical oncology2009
Enhanced expression of trophinin promotes invasive and metastatic potential of human gallbladder cancer cells.
Article in Journal of cancer research and clinical oncology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 23 citations in OpenAlex.
- Trophinin-associated protein expression correlates with shorter survival of patients with glioma: a study based on multiple data fusion analysis.Molecular biology reports · 2022Article
- Trophinin Is an Important Biomarker and Prognostic Factor in Osteosarcoma: Data Mining from Oncomine and the Cancer Genome Atlas Databases.BioMed research international · 2021Article
- New Family Members of FG Repeat Proteins and Their Unexplored Roles During Phase Separation.Frontiers in cell and developmental biology · 2021Review
- TROAP Promotes Breast Cancer Proliferation and Metastasis.BioMed research international · 2019Article
- Ets-1 regulates intracellular glutathione levels: key target for resistant ovarian cancer.Molecular cancer · 2013Article
- Ets-1 global gene expression profile reveals associations with metabolism and oxidative stress in ovarian and breast cancers.Cancer & metabolism · 2013Article
- ETS-1 protein regulates vascular endothelial growth factor-induced matrix metalloproteinase-9 and matrix metalloproteinase-13 expression in human ovarian carcinoma cell line SKOV-3.The Journal of biological chemistry · 2012Article
- ARK5 is associated with the invasive and metastatic potential of human breast cancer cells.Journal of cancer research and clinical oncology · 2012Article
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo study effects of trophinin on the metastatic potential of human gallbladder cancer cells and its potential mechanism. MATERIALS AND
methodsExpression of trophinin in the highly metastatic GBC-SDH(i) cells was investigated by real time RT-PCR and western blot. Recombinant expression plasmid vector of the human trophinin gene was constructed and transfected into GBC-SD cells. Effects of trophinin on the invasion of GBC-SD cells were investigated by adhesion assay and invasion assay in vitro. The siRNA was used to down-regulate the expression of trophinin. Some genes related to the invasion and metastasis of cancer were determined by real time RT-PCR and western blot. The pulmonary metastasis regulated by trophinin was determined in the nude mice.
resultsOverexpression of trophinin in GBC-SDH(i) cells was confirmed compared with its parental counterparts. Up-regulation of trophinin enhanced the in vitro invasion in the GBC-SD/TRO cells. The enhancement was associated with increasing integrin alpha3, MMP-7, MMP-9, and Ets-1 expression. The results were further demonstrated by RNA interference experiment in vitro. In in vivo study, we also demonstrated that trophinin-transfected gallbladder cancer cells had more pulmonary metastases than the vector-transfected one or its parental counterparts.
conclusionOverexpression of trophinin leads to a more invasive phenotype and metastatic potential in human gallbladder cancer, at least in part, through regulating integrin alpha3, MMP-7, MMP-9, and Ets-1 expression.
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