ArticlePflugers Archiv : European journal of physiology2009
Reactive oxygen species and inflammatory mediators enhance muscle spindles mechanosensitivity in rats.
Article in Pflugers Archiv : European journal of physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- International Society for the Advancement of Spine Surgery Statement: Restorative Neurostimulation for Chronic Mechanical Low Back Pain Resulting From Neuromuscular Instability.International journal of spine surgery · 2023Article
- Review
- Exaggerated exercise pressor reflex in type 2 diabetes: Potential role of oxidative stress.Autonomic neuroscience : basic & clinical · 2019Review
- Consecutive, Resting, Long-Duration Hyperoxic Exposures Alter Neuromuscular Responses During Maximal Strength Exercises in Trained Men.Frontiers in physiology · 2019Article
- Lipopolysaccharide-induced inflammation does not alter muscle spindle afferent mechanosensation or sensory integration in the spinal cord of adult mice.Physiological reports · 2018Article
- Bradykinin B2 receptor contributes to the exaggerated muscle mechanoreflex in rats with femoral artery occlusion.American journal of physiology. Heart and circulatory physiology · 2013Article
- Redox artifacts in electrophysiological recordings.American journal of physiology. Cell physiology · 2013Article
- Interactive processes link the multiple symptoms of fatigue in sport competition.Sports medicine (Auckland, N.Z.) · 2011Review
- Reactive oxygen species activate the group IV muscle afferents in resting and exercising muscle in rats.Pflugers Archiv : European journal of physiology · 2009Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We tested the hypothesis that reactive oxygen species (ROS) and inflammatory mediators affect transduction properties of muscle spindles. In rats, muscle spindles response to high-frequency vibration (HFV) was recorded before and after (1) injection of hydrogen peroxide (H2O2) in control rats and animals pre-treated with diclofenac (anti-inflammatory substance), (2) injection of bradykinin and (3) fatigue induced by muscle stimulation (MS) in control rats and rats receiving diclofenac, superoxide dismutase (SOD) or H2O2. Muscular oxidative stress and inflammation induced by H2O2 or MS were assessed by measurements of isoprostanes and IL-6 levels. In control rats, H2O2, bradykinin and MS significantly enhanced the HFV response. Pre-treatment with SOD abolished the post-MS-enhanced HFV response whereas diclofenac lowered the peak HFV response to MS and H2O2. H2O2 injection and MS elicited significant and similar increases in isoprostanes and IL-6. We report a direct modulation of muscle spindles mechanosensitivity by ROS and inflammatory mediators.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.