ReviewJournal of neurology2008
Subacute sclerosing panencephalitis.
Review in Journal of neurology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 159 citations in OpenAlex.
- Post-acute sequelae after Nipah virus infection: a systematic review and meta-analysis.EClinicalMedicine · 2026Article
- Preliminary evidence of cardiac dysfunction in subacute sclerosing panencephalitis: a systematic review and meta-analysis.Encephalitis (Seoul, Korea) · 2026Article
- Uncommon Presentation of Subacute Sclerosing Panencephalitis: Two Cases of Rapidly Progressive Parkinsonism.Journal of movement disorders · 2026Article
- How I do it: continuous intraventricular interferon alpha infusion in pediatric patients with subacute sclerosing panencephalitis.Acta neurochirurgica · 2025Article
- Subacute sclerosing panencephalitis as a re-emerging condition due to low vaccination coverage: a case-series.Italian journal of pediatrics · 2025Article
- CSF Interleukins-12, 17 and Interferon-γ Levels in Children with Subacute Sclerosing Panencephalitis.Indian journal of pediatrics · 2025Observational
- The Rare Case Presentation of Adult-Onset Fulminant Subacute Sclerosing Panencephalitis in a 24-Year-Old Male.Cureus · 2024Article
- Optical Coherence Tomography Angiographic Follow-Up in a Case of Subacute Sclerosing Panencephalitis and Unilateral Necrotising Retinitis.Neuro-ophthalmology (Aeolus Press) · 2024Article
- Periodic Jaw-Opening Myoclonus in Subacute Sclerosing Panencephalitis.Journal of movement disorders · 2023Article
- Viral-induced neuroinflammation: Different mechanisms converging to similar exacerbated glial responses.Frontiers in neuroscience · 2023Review
- Subacute Sclerosing Panencephalitis (SSPE): Experience from a Tertiary-Care Pediatric Center.Journal of neurosciences in rural practice · 2022Article
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- Subacute sclerosing panencephalitis and brain stem involvement: a rare combination.BMJ case reports · 2021Article
- Subacute Sclerosing Panencephalitis manifesting as Bell's palsy and bilateral macular necrotizing retinitis: an atypical presenting feature.Journal of ophthalmic inflammation and infection · 2021Article
- Advances in Antiviral Therapy for Subacute Sclerosing Panencephalitis.Molecules (Basel, Switzerland) · 2021Review
- Adult-Onset Subacute Sclerosing Panencephalitis With a 30-Year Latent Period.The Neurohospitalist · 2020Article
- Marine Morbilliviruses: Diversity and Interaction with Signaling Lymphocyte Activation Molecules.Viruses · 2019Review
- Neuroinflammation During RNA Viral Infections.Annual review of immunology · 2019Review
- Henipavirus infection of the central nervous system.Pathogens and disease · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Subacute sclerosing panencephalitis (SSPE) is a subacute encephalopathy of childhood and young adolescence. Infrequently, SSPE can occur in adults and pregnant women. It is caused by an aberrant measles virus, known as the SSPE virus. SSPE virus differs from wild-type measles viruses in the form of several mutations affecting the viral genome. The matrix gene is most commonly affected by these mutations. The characteristic clinical manifestations of SSPE include behavioral changes, cognitive decline, myoclonic jerks, seizures, abnormalities in vision, bilateral pyramidal signs and coma. Ocular changes may occur in up to 50% of patients. The most characteristic ophthalmological lesion is necrotizing retinitis. Cortical blindness can be the early feature of SSPE. The diagnosis of SSPE is often difficult in the early stages. In a typical case diagnosis is based on clinical, electroencephalographic, and cerebrospinal fluid findings. At present, there is no effective treatment to completely cure SSPE. Oral isoprinosine and intrathecal or intraventricular alpha-interferon may prolong survival to some extent. Immunization against measles is currently the most effective strategy against SSPE.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.