Evidence map›Paper›PMID 18846265›Full record

ArticleExpert review of dermatology2007

Mechanism of UV-related carcinogenesis and its contribution to nevi/melanoma.

Brozyna Anna, Zbytek Blazej, Granese Jacqueline, Carlson J Andrew, Ross Jeffrey, Slominski Andrzej

Open access · greenAbstract read
In one paragraph

Article in Expert review of dermatology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 155 citations in OpenAlex.

  1. SkinApplied and environmental microbiology · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Uncovering Anti-Melanoma Mechanisms ofInternational journal of molecular sciences · 2025
    Article
  9. Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Precision Oncology in Melanoma: Changing Practices.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024
    Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Brozyna AnnaDepartment of Medical Biology, Nicolaus Copernicus University, Torun, Poland, Tel: (4856)611-4776, , E-mail: abrozyna@biol.uni.torun.pl.
Zbytek Blazej
Granese Jacqueline
Carlson J Andrew
Ross Jeffrey
Slominski Andrzej
University of Tennessee Health Science Center · USAlbany Medical Center Hospital · USNicolaus Copernicus University · PL

Funding

Novel Biosynthetic Pathway for Secosteroids and the SkinR01AR052190 · NIAMS · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI POSTLETHWAITE, ARNOLD E, SLOMINSKI, ANDRZEJ T · 2006 to 2013
$2.2M
Role of CRH in skin physiology and pathologyR01AR047079 · NIAMS · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI SLOMINSKI, ANDRZEJ T · 2002 to 2004
$708k
NIAMS NIH HHS R01 AR047079NIAMS NIH HHS R01 AR052190
6 · The paper itself

Abstract

Melanoma consists 4-5 % of all skin cancers, but it contributes to 71-80 % of skin cancers deaths. UV light affects cell and tissue homeostasis due to its damaging effects on DNA integrity and modification of expression of a plethora of genes. DNA repair systems protect cells from UV-induced lesions. Several animal models of melanoma have been developed (Xiphophorus, Opossum Monodelphis domestica, mouse models and human skin engrafts into other animals). This review discusses possible links between UV and genes significantly related to melanoma but does not discuss melanoma genetics. These include oncogenes, tumor suppressor genes, genes related to melanocyte-keratinocyte and melanocyte-matrix interaction, growth factors and their receptors, CRH, ACTH, α-MSH, glucocorticoids, ID1, NF-kappaB and vitamin D3.

Identifiers

PMID18846265
PMCPMC2564815
OpenAlexW1973034565

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.