ArticleDose-response : a publication of International Hormesis Society2008
Evidence for radiation hormesis after in vitro exposure of human lymphocytes to low doses of ionizing radiation.
Article in Dose-response : a publication of International Hormesis Society, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 47 citations in OpenAlex.
- High-Accuracy Relative Biological Effectiveness Values Following Low-Dose Thermal Neutron Exposures Support Bimodal Quality Factor Response with Neutron Energy.International journal of molecular sciences · 2022Article
- Effect of X-ray exposure during hysterosalpingography on capabilities of female germ cells.Journal of assisted reproduction and genetics · 2021Article
- Different responses of normal cells (red blood cells) and cancer cells (K562 and K562/Dox cells) to low-doseMolecular and clinical oncology · 2021Article
- Effective Doses of Ionizing Radiation during Therapeutic Peat Mud Treatment from a Deposit in the Knyszyn Forest (Northeastern Poland).International journal of environmental research and public health · 2020Article
- Review
- Effect of Photon Hormesis on Dose Responses to Alpha Particles in Zebrafish Embryos.International journal of molecular sciences · 2017Article
- Hormetic Effect of Berberine Attenuates the Anticancer Activity of Chemotherapeutic Agents.PloS one · 2015Article
- Radiation-hormesis phenotypes, the related mechanisms and implications for disease prevention and therapy.Journal of cell communication and signaling · 2014Article
- Correcting systemic deficiencies in our scientific infrastructure.Dose-response : a publication of International Hormesis Society · 2014Article
- Lack of genomic instability in bone marrow cells of SCID mice exposed whole-body to low-dose radiation.International journal of environmental research and public health · 2013Article
- Small γ-Ray Doses Prevent Rather than Increase Lung Tumors in Mice.Dose-response : a publication of International Hormesis Society · 2012Article
- Identification of proteins secreted into the medium by human lymphocytes irradiated in vitro with or without adaptive environments.Health physics · 2012Article
- No Evidence for the In Vivo Induction of Genomic Instability by Low Doses of CS Gamma Rays in Bone Marrow Cells of BALB/CJ and C57BL/6J Mice.Dose-response : a publication of International Hormesis Society · 2012Article
- Effects of acute low doses of gamma-radiation on erythrocytes membrane.Radiation and environmental biophysics · 2011Article
- Mean cancer mortality rates in low versus high elevation counties in Texas.Dose-response : a publication of International Hormesis Society · 2010Article
- Radiation-stimulated epigenetic reprogramming of adaptive-response genes in the lung: an evolutionary gift for mounting adaptive protection against lung cancer.Dose-response : a publication of International Hormesis Society · 2009Article
- Modification in the expression of Mre11/Rad50/Nbs1 complex in low dose irradiated human lymphocytes.Dose-response : a publication of International Hormesis Society · 2009Article
- It's time for a new low-dose-radiation risk assessment paradigm--one that acknowledges hormesis.Dose-response : a publication of International Hormesis Society · 2008Article
- Influence of Individual Radiosensitivity on the Hormesis Phenomenon: Toward a Mechanistic Explanation Based on the Nucleoshuttling of ATM Protein.Dose-response : a publication of International Hormesis SocietyReview
- Augmentation of Neurotoxicity of Anticancer Drugs by X-Ray Irradiation.In vivo (Athens, Greece)Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous research has demonstrated that adding a very small gamma-ray dose to a small alpha radiation dose can completely suppress lung cancer induction by alpha radiation (a gamma-ray hormetic effect). Here we investigated the possibility of gamma-ray hormesis during low-dose neutron irradiation, since a small contribution to the total radiation dose from neutrons involves gamma rays. Using binucleated cells with micronuclei (micronucleated cells) among in vitro monoenergetic-neutron-irradiated human lymphocytes as a measure of residual damage, we investigated the influence of the small gamma-ray contribution to the dose on suppressing residual damage. We used residual damage data from previous experiments that involved neutrons with five different energies (0.22-, 0.44-, 1.5-, 5.9-, and 13.7-million electron volts [MeV]). Corresponding gamma-ray contributions to the dose were approximately 1%, 1%, 2%, 6%, and 6%, respectively. Total absorbed radiation doses were 0, 10, 50, and 100 mGy for each neutron source. We demonstrate for the first time a protective effect (reduced residual damage) of the small gamma-ray contribution to the neutron dose. Using similar data for exposure to gamma rays only, we also demonstrate a protective effect of 10 mGy (but not 50 or 100 mGy) related to reducing the frequency of micronucleated cells to below the spontaneous level.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.