ReviewCancer gene therapy2009
Transcription factors: their potential as targets for an individualized therapeutic approach to cancer.
Review in Cancer gene therapy, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 51 citations in OpenAlex.
- STAT3 and SOX-5 induce BRG1-mediated chromatin remodeling of RORCE2 in Th17 cells.Communications biology · 2024Article
- Analysis of regulatory sequences in exosomal DNA of NANOGP8.PloS one · 2023Article
- SOX-5 activates a novel RORγt enhancer to facilitate experimental autoimmune encephalomyelitis by promoting Th17 cell differentiation.Nature communications · 2021Article
- Decreased Expression ofInternational journal of molecular sciences · 2020Article
- Regulation of GLI1 by cis DNA elements and epigenetic marks.DNA repair · 2019Article
- NKX2-2 Suppresses Osteosarcoma Metastasis and Proliferation by Downregulating Multiple Target Genes.Journal of Cancer · 2018Article
- Identification of novel prostate cancer drivers using RegNetDriver: a framework for integration of genetic and epigenetic alterations with tissue-specific regulatory network.Genome biology · 2017Article
- Yin Yang 1 (YY1): Regulation of Survivin and Its Role In Invasion and Metastasis.Critical reviews in oncogenesis · 2017Review
- Targeted Cancer Therapy: Vital Oncogenes and a New Molecular Genetic Paradigm for Cancer Initiation Progression and Treatment.International journal of molecular sciences · 2016Review
- A Computational Drug Repositioning Approach for Targeting Oncogenic Transcription Factors.Cell reports · 2016Article
- Polyphenol Compound as a Transcription Factor Inhibitor.Nutrients · 2015Review
- Imaging tumor growth non-invasively using expression of MagA or modified ferritin subunits to augment intracellular contrast for repetitive MRI.Molecular imaging and biology · 2014Article
- Transcriptional control of cancer metastasis.Trends in cell biology · 2013Review
- Optimization of novel nipecotic bis(amide) inhibitors of the Rho/MKL1/SRF transcriptional pathway as potential anti-metastasis agents.Bioorganic & medicinal chemistry letters · 2013Article
- Quantitative, solution-phase profiling of multiple transcription factors in parallel.Analytical and bioanalytical chemistry · 2013Article
- Effect of antisense oligodeoxynucleotide targeted against NF-κB/P65 on cell proliferation and tumorigenesis of gastric cancer.Clinical and experimental medicine · 2013Article
- Organotypic liver culture models: meeting current challenges in toxicity testing.Critical reviews in toxicology · 2012Review
- Nuclear factor-κB expression is predictive of overall survival in patients with cutaneous melanoma.Oncology letters · 2010Article
- Adenoviral targeting of gene expression to tumors.Cancer gene therapy · 2010Article
- CCAAT/enhancer-binding protein beta: its role in breast cancer and associations with receptor tyrosine kinases.Expert reviews in molecular medicine · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pro-cancer signals are controlled by the expression and transcription of oncogenes. Transcription of DNA is dependent on the spatially and temporally coordinated interaction between transcriptional machinery (RNA polymerase II, transcription factors (TFs)) and transcriptional regulatory components (promoter elements, enhancers, silencers and locus control regions). Unique TFs have been identified in association with cancer. This review summarizes key oncogene-related TFs and organizes their pro-cancer activity according to the six hallmark functions (self sufficiency in growth signals, insensitivity to growth-inhibitory signals, evasion of programmed cell death, limitless replicative potential, sustained angiogenesis and metastatic spread) proposed as constituting the infrastructure of the malignant process.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.