Evidence map›Paper›PMID 18846099›Full record

ReviewNature reviews. Immunology2008

Mammalian glycosylation in immunity.

Jamey D Marth, Prabhjit K Grewal

Abstract readReview
In one paragraph

Review in Nature reviews. Immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 346 papers.

0numbers the graph read from it
0cells of the map it votes in
346citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

346 citing papers in PubMed.

  1. Add-OnNutrients · 2024
    Trial
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  5. Review
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  9. Review
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  15. Review
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  17. Calsyntenin-3 suppresses inflammation via inhibition of TLR N-glycosylation and membrane localization.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  18. Article
  19. Metabolomic profiling ofmSystems · 2025
    Article
  20. Article

286 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jamey D MarthDepartment of Cellular and Molecular Medicine, the Howard Hughes Medical Institute, University of California San Diego, La Jolla, California 92093, USA. jmarth@ucsd.edu
Prabhjit K Grewal

Funding

Structural Basis of Immune Recognition of Glycosylated AntigensU54GM062116 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI BLIXT, OLA KLAS · 2001 to 2010
$80.3M
The Interaction of TPO and Integrins in Hematopoiesis CellsP01HL078784 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GINSBERG, MARK HOWARD · 2005 to 2019
$28.3M
Siglec Modulation of Inflammation in Humans and MiceP01HL057345 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ESKO, JEFFREY D · 1997 to 2012
$24.1M
REGULATION OF SIALOSIDE EXPRESSION IN LEUKOCYTESR01AI050143 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI PAULSON, JAMES C · 2003 to 2018
$7.0M
MAMMALIAN SIALIC ACID BINDING PROTEINSR01GM060938 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI PAULSON, JAMES C · 2000 to 2010
$4.0M
NHLBI NIH HHS HL57345NHLBI NIH HHS HL78784NHLBI NIH HHS P01 HL057345NHLBI NIH HHS P01 HL078784NIAID NIH HHS R01 AI050143NIGMS NIH HHS GM62116NIGMS NIH HHS R01 GM060938NIGMS NIH HHS U54 GM062116
6 · The paper itself

Abstract

Glycosylation produces a diverse and abundant repertoire of glycans, which are collectively known as the glycome. Glycans are one of the four fundamental macromolecular components of all cells, and are highly regulated in the immune system. Their diversity reflects their multiple biological functions that encompass ligands for proteinaceous receptors known as lectins. Since the discovery that selectins and their glycan ligands are important for the regulation of leukocyte trafficking, it has been shown that additional features of the vertebrate immune system are also controlled by endogenous cellular glycosylation. This Review focuses on the emerging immunological roles of the mammalian glycome.

Indexed as

AnimalsGlycosylationHumansImmunity, InnatePolysaccharidesPolysaccharides

Identifiers

PMID18846099
PMCPMC2768770

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.