ArticleJournal of acquired immune deficiency syndromes (1999)2008
Associations of chemokine receptor polymorphisms With HIV-1 mother-to-child transmission in sub-Saharan Africa: possible modulation of genetic effects by antiretrovirals.
Article in Journal of acquired immune deficiency syndromes (1999), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- Reduced CCR5 expression among Uganda HIV controllers.Retrovirology · 2023Article
- Understanding Viral and Immune Interplay During Vertical Transmission of HIV: Implications for Cure.Frontiers in immunology · 2021Review
- Article
- CCR2 polymorphism and HIV: mutation in both mother and child is associated with higher transmission.International journal of biochemistry and molecular biology · 2019Article
- IMPLICATION OF FIVE AIDS RELATED GENES IN MOTHER-TO-CHILD TRANSMISSION AND ACQUISITION OF HUMAN IMMUNODEFICIENCY VIRUS 1 IN CAMEROON.African journal of infectious diseases · 2019Article
- Host Molecular Factors and Viral Genotypes in the Mother-to-Child HIV-1 Transmission in Sub-Saharan Africa.Journal of public health in Africa · 2017Review
- Host factors and early treatments to restrict paediatric HIV infection and early disease progression.Journal of virus eradication · 2015Review
- The CD4 C868T Polymorphism and Its Correlation with HIV-1 Infection in a Chinese Population.AIDS research and human retroviruses · 2015Article
- Genetic diversity and linkage disequilibrium in the chemokine receptor CCR2-CCR5 region among individuals and populations.Cytokine · 2013Article
- CCR5 promoter haplotypes differentially influence CCR5 expression on natural killer and T cell subsets in ethnically divergent HIV-1 uninfected South African populations.Immunogenetics · 2012Article
- Naturally-occurring genetic variants in human DC-SIGN increase HIV-1 capture, cell-transfer and risk of mother-to-child transmission.PloS one · 2012Article
- HIV-1 co-receptor usage: influence on mother-to-child transmission and pediatric infection.Journal of translational medicine · 2011Review
- Host factors that influence mother-to-child transmission of HIV-1: genetics, coinfections, behavior and nutrition.Future virology · 2011Article
- CCR5, RANTES and SDF-1 polymorphisms and mother-to-child HIV-1 transmission.International journal of immunogenetics · 2010Article
- APOE epsilon4 and MBL-2 O/O genotypes are associated with neurocognitive impairment in HIV-infected plasma donors.AIDS (London, England) · 2010Article
- Host genes associated with HIV/AIDS: advances in gene discovery.Trends in genetics : TIG · 2010Review
- Functional genetic variants in DC-SIGNR are associated with mother-to-child transmission of HIV-1.PloS one · 2009Article
- Single-dose nevirapine exposure affects T cell response and cytokine levels in HIV type 1-infected women.AIDS research and human retroviruses · 2009Article
- CCR2-64I polymorphism is associated with lower maternal HIV-1 viral load and reduced vertical HIV-1 transmission.Journal of acquired immune deficiency syndromes (1999) · 2009Article
- Host genetic determinants of human immunodeficiency virus infection and disease progression in children.Pediatric research · 2009Review
Corrections and comments
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Authors and funding
13 authors at 8 institutions in 3 countries.
Funding
Abstract
backgroundHIV-1 mother-to-child transmission (MTCT) remains an important route of infection in sub-Saharan Africa.
methodsGenetic variants in CCR5 promoter, CCR2, CX3CR1, and Stromal cell-derived factor-1 (SDF-1) genes were determined in 980 infants from sub-Saharan Africa using real-time polymerase chain reaction to determine association with MTCT.
resultsIn antiretroviral-naive mother-infant pairs (n = 637), CCR5 promoter polymorphisms at positions 59029: A allele vs. G/G [odds ratio (OR): 1.61, 95% confidence interval (CI): 1.04 to 2.48; P = 0.032] and 59356: T allele vs. C/C (OR: 0.63, 95% CI: 0.41 to 0.96; P = 0.033) and CCR2-180: G allele vs. A/A (OR: 3.32, 95% CI: 1.13 to 9.73; P = 0.029) were associated with risk of MTCT. Treatment of HIV-1-infected mothers and infants with single-dose nevirapine or perinatal zidovudine altered but did not eliminate the association of genetic variants with MTCT.
conclusionsCCR5 promoter, CCR2, and CX3CR1 polymorphisms were associated with risk of MTCT likely through their role as an HIV-1 coreceptor or by modulating the early immune response. Host genetics may continue to alter MTCT when short-course interventions that only partially suppress virus are used. These findings will need to be confirmed in validation cohorts with a large number of infected infants.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.