ArticleGenetics2008
Practical applications of the bioinformatics toolbox for narrowing quantitative trait loci.
Article in Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed.
- Mouse Genome Database (MGD): Knowledgebase for mouse-human comparative biology.Nucleic acids research · 2021Article
- A multi-omics digital research object for the genetics of sleep regulation.Scientific data · 2019Article
- A systems genetics resource and analysis of sleep regulation in the mouse.PLoS biology · 2018Article
- Epidermal growth factor receptor restoration rescues the fatty liver regeneration in mice.American journal of physiology. Endocrinology and metabolism · 2017Article
- Transgenic overexpression of VEGF-C induces weight gain and insulin resistance in mice.Scientific reports · 2016Article
- Weak Epistasis Generally Stabilizes Phenotypes in a Mouse Intercross.PLoS genetics · 2016Article
- Genome-Wide Identification of QTL for Seed Yield and Yield-Related Traits and Construction of a High-Density Consensus Map for QTL Comparison in Brassica napus.Frontiers in plant science · 2016Article
- Collaborative Cross and Diversity Outbred data resources in the Mouse Phenome Database.Mammalian genome : official journal of the International Mammalian Genome Society · 2015Article
- Genetic Regulation of Female Sexual Maturation and Longevity Through Circulating IGF1.The journals of gerontology. Series A, Biological sciences and medical sciences · 2015Article
- Genetic regulation of life span, metabolism, and body weight in Pohn, a new wild-derived mouse strain.The journals of gerontology. Series A, Biological sciences and medical sciences · 2013Article
- Natural genetic variation of integrin alpha L (Itgal) modulates ischemic brain injury in stroke.PLoS genetics · 2013Article
- A major X-linked locus affects kidney function in mice.Molecular genetics and genomics : MGG · 2012Article
- Susceptibility to progressive Cryptococcus neoformans pulmonary infection is regulated by loci on mouse chromosomes 1 and 9.Infection and immunity · 2012Article
- Mapping quantitative trait loci onto a phylogenetic tree.Genetics · 2012Article
- Using bioinformatics and systems genetics to dissect HDL-cholesterol genetics in an MRL/MpJ x SM/J intercross.Journal of lipid research · 2012Article
- Article
- The search for longevity and healthy aging genes: insights from epidemiological studies and samples of long-lived individuals.The journals of gerontology. Series A, Biological sciences and medical sciences · 2012Review
- Healing quantitative trait loci in a combined cross analysis using related mouse strain crosses.Heredity · 2012Article
- Genome-wide association for methamphetamine sensitivity in an advanced intercross mouse line.Genes, brain, and behavior · 2012Article
- Forward genetic approaches to understanding complex behaviors.Current topics in behavioral neurosciences · 2012Review
Corrections and comments
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Authors and funding
4 authors.
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Abstract
Dissecting the genes involved in complex traits can be confounded by multiple factors, including extensive epistatic interactions among genes, the involvement of epigenetic regulators, and the variable expressivity of traits. Although quantitative trait locus (QTL) analysis has been a powerful tool for localizing the chromosomal regions underlying complex traits, systematically identifying the causal genes remains challenging. Here, through its application to plasma levels of high-density lipoprotein cholesterol (HDL) in mice, we demonstrate a strategy for narrowing QTL that utilizes comparative genomics and bioinformatics techniques. We show how QTL detected in multiple crosses are subjected to both combined cross analysis and haplotype block analysis; how QTL from one species are mapped to the concordant regions in another species; and how genomewide scans associating haplotype groups with their phenotypes can be used to prioritize the narrowed regions. Then we illustrate how these individual methods for narrowing QTL can be systematically integrated for mouse chromosomes 12 and 15, resulting in a significantly reduced number of candidate genes, often from hundreds to <10. Finally, we give an example of how additional bioinformatics resources can be combined with experiments to determine the most likely quantitative trait genes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.