ArticleGenetics2008
Complex genetics control natural variation in Arabidopsis thaliana resistance to Botrytis cinerea.
Article in Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed, 118 citations in OpenAlex.
- Integrative GWAS and transcriptomic analyses reveal markers and candidate genes associated with resistance toHorticulture research · 2026Article
- When Metabolomics Meets Quantitative Genetics: An Integrative Strategy to Elucidate Plant Resistance Mechanisms.Plant, cell & environment · 2026Review
- Winning by Losing: Exploiting Modified Plant Susceptibility Genes to Counteract Necrotrophic Fungal Pathogens.Plant biotechnology journal · 2025Review
- Guns in rosettes: The Arabidopsis chemical weapons arsenal.Plant physiology · 2025Review
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- The necrotrophJournal of ginseng research · 2022Article
- Identification of genetic loci in lettuce mediating quantitative resistance to fungal pathogens.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Article
- The NecrotrophFrontiers in plant science · 2022Article
- Pinpointing secondary metabolites that shape the composition and function of the plant microbiome.Journal of experimental botany · 2021Review
- Pathogen Genetic Control of Transcriptome Variation in theGenetics · 2020Article
- Root-specific camalexin biosynthesis controls the plant growth-promoting effects of multiple bacterial strains.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
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- 97 Shades of Gray: Genetic Interactions of the Gray Mold,The Plant cell · 2019Article
- Interactions of Tomato andThe Plant cell · 2019Article
- Daniel J. Kliebenstein.The Plant cell · 2018Article
- Digital Imaging Combined with Genome-Wide Association Mapping Links Loci to Plant-Pathogen Interaction Traits.Plant physiology · 2018Article
- Genome-wide association mapping in Arabidopsis identifies novel genes underlying quantitative disease resistance to Alternaria brassicae.Molecular plant pathology · 2018Article
- Plastic Transcriptomes Stabilize Immunity to Pathogen Diversity: The Jasmonic Acid and Salicylic Acid Networks within the Arabidopsis/The Plant cell · 2017Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The genetic architecture of plant defense against microbial pathogens may be influenced by pathogen lifestyle. While plant interactions with biotrophic pathogens are frequently controlled by the action of large-effect resistance genes that follow classic Mendelian inheritance, our study suggests that plant defense against the necrotrophic pathogen Botrytis cinerea is primarily quantitative and genetically complex. Few studies of quantitative resistance to necrotrophic pathogens have used large plant mapping populations to dissect the genetic structure of resistance. Using a large structured mapping population of Arabidopsis thaliana, we identified quantitative trait loci influencing plant response to B. cinerea, measured as expansion of necrotic lesions on leaves and accumulation of the antimicrobial compound camalexin. Testing multiple B. cinerea isolates, we identified 23 separate QTL in this population, ranging in isolate-specificity from being identified with a single isolate to controlling resistance against all isolates tested. We identified a set of QTL controlling accumulation of camalexin in response to pathogen infection that largely colocalized with lesion QTL. The identified resistance QTL appear to function in epistatic networks involving three or more loci. Detection of multilocus connections suggests that natural variation in specific signaling or response networks may control A. thaliana-B. cinerea interaction in this population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.