ArticleGenetics2008
Loss of the histone variant H2A.Z restores capping to checkpoint-defective telomeres in Drosophila.
Article in Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 18 citations in OpenAlex.
- In thebioRxiv : the preprint server for biology · 2026Article
- The Drosophila histone variant H2Av facilitates Notch signaling activity in a two-tier regulatory fashion.Cell communication and signaling : CCS · 2025Article
- TheG3 (Bethesda, Md.) · 2018Article
- Histone depletion prevents telomere fusions in pre-senescent cells.PLoS genetics · 2018Article
- From Embryo to Adult: piRNA-Mediated Silencing throughout Germline Development inG3 (Bethesda, Md.) · 2017Article
- Coordination of transposon expression with DNA replication in the targeting of telomeric retrotransposons in Drosophila.The EMBO journal · 2014Article
- Telomeric repeats act as nucleosome-disfavouring sequences in vivo.Nucleic acids research · 2014Article
- The variant histone H2A.V of Drosophila--three roles, two guises.Chromosoma · 2013Review
- A hypomorphic mutation reveals a stringent requirement for the ATM checkpoint protein in telomere protection during early cell division in Drosophila.G3 (Bethesda, Md.) · 2013Article
- One identity or more for telomeres?Frontiers in oncology · 2013Article
- Acetylation of H2A.Z is a key epigenetic modification associated with gene deregulation and epigenetic remodeling in cancer.Genome research · 2012Article
- HipHop interacts with HOAP and HP1 to protect Drosophila telomeres in a sequence-independent manner.The EMBO journal · 2010Article
- Chromatin remodelling beyond transcription: the INO80 and SWR1 complexes.Nature reviews. Molecular cell biology · 2009Review
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The conserved histone variant H2A.Z fulfills many functions by being an integral part of the nucleosomes placed at specific regions of the genome. Telomeres cap natural ends of chromosomes to prevent their recognition as double-strand breaks. At yeast telomeres, H2A.Z prevents the spreading of silent chromatin into proximal euchromatin. A role for H2A.Z in capping, however, has not been reported in any organism. Here, I uncover such a role for Drosophila H2A.Z. Loss of H2A.Z, through mutations in either its gene or the domino gene for the Swr1 chromatin-remodeling protein, suppressed the fusion of telomeres that lacked the protection of checkpoint proteins: ATM, ATR, and the Mre11-Rad50-NBS complex. Loss of H2A.Z partially restores the loading of the HOAP capping protein, possibly accounting for the partial restoration in capping. I propose that, in the absence of H2A.Z, checkpoint-defective telomeres adopt alternative structures, which are permissive for the loading of the capping machinery at Drosophila telomeres.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.