ArticleProceedings of the National Academy of Sciences of the United States of America2008
Temporal control of the dephosphorylation of Cdk substrates by mitotic exit pathways in budding yeast.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 39 citations in OpenAlex.
- Article
- A new layer of regulation of chromosomal passenger complex (CPC) translocation in budding yeast.Molecular biology of the cell · 2023Article
- Functional tug of war between kinases, phosphatases, and the Gcn5 acetyltransferase in chromatin and cell cycle checkpoint controls.G3 (Bethesda, Md.) · 2023Article
- Yeast Fin1-PP1 dephosphorylates an Ipl1 substrate, Ndc80, to remove Bub1-Bub3 checkpoint proteins from the kinetochore during anaphase.PLoS genetics · 2021Article
- The Multiple Roles of the Cdc14 Phosphatase in Cell Cycle Control.International journal of molecular sciences · 2020Review
- The Opposing Functions of Protein Kinases and Phosphatases in Chromosome Bipolar Attachment.International journal of molecular sciences · 2019Review
- How the cell cycle clock ticks.Molecular biology of the cell · 2019Article
- Phosphoproteome dynamics during mitotic exit in budding yeast.The EMBO journal · 2018Article
- Sequential phosphorylation of CST subunits by different cyclin-Cdk1 complexes orchestrate telomere replication.Cell cycle (Georgetown, Tex.) · 2017Article
- A Clb/Cdk1-mediated regulation of Fkh2 synchronizesNPJ systems biology and applications · 2017Article
- Fin1-PP1 Helps Clear Spindle Assembly Checkpoint Protein Bub1 from Kinetochores in Anaphase.Cell reports · 2016Article
- Cdc14 phosphatase: warning, no delay allowed for chromosome segregation!Current genetics · 2016Review
- Cdc14 targets the Holliday junction resolvase Yen1 to the nucleus in early anaphase.Cell cycle (Georgetown, Tex.) · 2014Article
- Slk19 clusters kinetochores and facilitates chromosome bipolar attachment.Molecular biology of the cell · 2013Article
- Article
- Coordination of chromatid separation and spindle elongation by antagonistic activities of mitotic and S-phase CDKs.PLoS genetics · 2013Article
- Cdc14 phosphatases preferentially dephosphorylate a subset of cyclin-dependent kinase (Cdk) sites containing phosphoserine.The Journal of biological chemistry · 2012Article
- Dependence of Chs2 ER export on dephosphorylation by cytoplasmic Cdc14 ensures that septum formation follows mitosis.Molecular biology of the cell · 2012Article
- A quantitative model for cyclin-dependent kinase control of the cell cycle: revisited.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2011Review
- Regulation of exit from mitosis in multinucleate Ashbya gossypii cells relies on a minimal network of genes.Molecular biology of the cell · 2011Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The temporal phosphorylation of cell cycle-related proteins by cyclin-dependent kinases (Cdks) is critical for the correct order of cell cycle events. In budding yeast, CDC28 encodes the only Cdk and its association with various cyclins governs the temporal phosphorylation of Cdk substrates. S-phase Cdk substrates are phosphorylated earlier than mitotic Cdk substrates, which ensures the sequential order of DNA synthesis and mitosis. However, it remains unclear whether Cdk substrates are dephosphorylated in temporally distinct windows. Cdc14 is a conserved protein phosphatase responsible for the dephosphorylation of Cdk substrates. In budding yeast, FEAR (Cdc14 early anaphase release) and MEN (mitotic exit network) activate phosphatase Cdc14 by promoting its release from the nucleolus in early and late anaphase, respectively. Here, we show that the sequential Cdc14 release and the distinct degradation timing of different cyclins provides the molecular basis for the differential dephosphorylation windows of S-phase and mitotic cyclin substrates. Our data also indicate that FEAR-induced dephosphorylation of S-phase Cdk substrates facilitates anaphase progression, revealing an extra layer of mitotic regulation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.