ArticleThe Journal of biological chemistry2008
Trimerization and triple helix stabilization of the collagen XIX NC2 domain.
Article in The Journal of biological chemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Around the collagen triple helix: an introduction to studying associated genetic and acquired diseases.Matrix biology : journal of the International Society for Matrix Biology · 2025Review
- Enhanced Bioprinting of 3D Corneal Stroma Patches with Reliability, Assessing Product Consistency and Quality through Optimized Electron Beam Sterilization.Advanced healthcare materials · 2025Article
- Collagen formation, function and role in kidney disease.Nature reviews. Nephrology · 2025Review
- Abnormalities in esophageal smooth muscle induced by mutations in collagen XIX.Histochemistry and cell biology · 2022Article
- Type XIX collagen: a promising biomarker from the basement membranes.Neural regeneration research · 2020Review
- Transcriptome profiling reveals transcriptional and alternative splicing regulation in the early embryonic development of hair follicles in the cashmere goat.Scientific reports · 2019Article
- Reversible Covalent End-Capping of Collagen Model Peptides.Chemistry (Weinheim an der Bergstrasse, Germany) · 2019Article
- Structural insight for chain selection and stagger control in collagen.Scientific reports · 2016Article
- Minicollagen cysteine-rich domains encode distinct modes of polymerization to form stable nematocyst capsules.Scientific reports · 2016Article
- The cysteine-rich region of type VII collagen is a cystine knot with a new topology.The Journal of biological chemistry · 2014Article
- Vascular Ehlers-Danlos syndrome mutations in type III collagen differently stall the triple helical folding.The Journal of biological chemistry · 2013Article
- The NC2 domain of type IX collagen determines the chain register of the triple helix.The Journal of biological chemistry · 2012Article
- Crystal structure of the human collagen XV trimerization domain: a potent trimerizing unit common to multiplexin collagens.Matrix biology : journal of the International Society for Matrix Biology · 2011Article
- The collagen family.Cold Spring Harbor perspectives in biology · 2011Review
- Collagen XIXa1 is crucial for motor axon navigation at intermediate targets.Development (Cambridge, England) · 2010Article
- The NC2 domain of collagen IX provides chain selection and heterotrimerization.The Journal of biological chemistry · 2010Article
- Kinetic hysteresis in collagen folding.Biophysical journal · 2010Article
- Expanding the family of collagen proteins: recombinant bacterial collagens of varying composition form triple-helices of similar stability.Biomacromolecules · 2010Article
- Crystal structure of human collagen XVIII trimerization domain: A novel collagen trimerization Fold.Journal of molecular biology · 2009Article
- Supramolecular assembly of electrostatically stabilized, hydroxyproline-lacking collagen-mimetic peptides.Biomacromolecules · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mechanisms of chain selection and assembly of fibril-associated collagens with interrupted triple helices (FACITs) must differ from that of fibrillar collagens, since they lack the characteristic C-propeptide. We analyzed two carboxyl-terminal noncollagenous domains, NC2 and NC1, of collagen XIX as potential trimerization units and found that NC2 forms a stable trimer and substantially stabilizes a collagen triple helix attached to either end. In contrast, the NC1 domain requires formation of an adjacent collagen triple helix to form interchain disulfide bridges. The NC2 domain of collagen XIX and probably of other FACITs is responsible for chain selection and trimerization.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.