ArticleClinical immunology (Orlando, Fla.)2009
Can oligomeric T-cell receptor be used as a tool to detect viral peptide epitopes on infected cells?
Article in Clinical immunology (Orlando, Fla.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 14 citations in OpenAlex.
- CAR-T Therapy in HIV: Pioneering Advances and Navigating Challenges.Infectious diseases & immunity · 2024Article
- Human cytomegalovirus-specific T-cell receptor engineered for high affinity and soluble expression using mammalian cell display.The Journal of biological chemistry · 2019Article
- Development of a T-cell receptor multimer with high avidity for detecting a naturally presented tumor-associated antigen on osteosarcoma cells.Cancer science · 2019Article
- Core-based lipid nanoparticles as a nanoplatform for delivery of near-infrared fluorescent imaging agents.American journal of nuclear medicine and molecular imaging · 2014Article
- Article
- Evidence that the density of self peptide-MHC ligands regulates T-cell receptor signaling.PloS one · 2012Article
- Binding of TCR multimers and a TCR-like antibody with distinct fine-specificities is dependent on the surface density of HLA complexes.PloS one · 2012Article
- Interaction of streptavidin-based peptide-MHC oligomers (tetramers) with cell-surface TCRs.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- A novel composite immunotoxin that suppresses rabies virus production by the infected cells.Journal of immunological methods · 2010Article
- Kinetics of early T cell receptor signaling regulate the pathway of lytic granule delivery to the secretory domain.Immunity · 2009Article
- Capsid antigen presentation flags human hepatocytes for destruction after transduction by adeno-associated viral vectors.The Journal of clinical investigation · 2009Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
We have utilized soluble HIV Gag-specific T-cell receptor (TCR) D3 with low affinity and TCR-like antibody 25-D1.16 recognizing its natural peptide-MHC (pMHC) ligand with high affinity to determine how affinity and off-rate of the receptor-pMHC interactions affect the sensitivity of pMHC detection on the cell surface. We found that with soluble TCR cognate pMHCs can be detected only at relatively high cell surface densities when the TCR was oligomerized using either Streptavidin or quantum dot (QD) scaffolds. While the higher affinity probe led to a greater sensitivity of pMHC detection, monomers and oligomers of the probe showed essentially the same detection limit, which is restricted by the sensitivity of standard flow cytometry technique. We have also shown that imaging of QD/TCR specifically bound to cognate pMHC on the cell surface yielded a very bright fluorescent signal that can enhance the sensitivity of viral peptide detection on infected cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.