ArticleAmerican journal of preventive medicine2008
Economic evaluation of a neural tube defect recurrence-prevention program.
Article in American journal of preventive medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- Economic burden of neural tube defects and impact of prevention with folic acid: a literature review.European journal of pediatrics · 2011Pooled it
- Long-term trends and disparities in primary intracranial germ cell tumor incidence and mortality for child and adolescent in the USA.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Article
- A case study of ReachAnother Foundation as a change champion for developing spina bifida neurosurgical care and advocating for primary prevention in Ethiopia.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023Review
- Economic evaluation of Zika Contraception Access Network in Puerto Rico during the 2016-17 Zika virus outbreak.Contraception · 2022Article
- Impact of Voluntary Folic Acid Fortification of Corn Masa Flour on RBC Folate Concentrations in the U.S. (NHANES 2011-2018).Nutrients · 2021Article
- Quantifying Family Spillover Effects in Economic Evaluations: Measurement and Valuation of Informal Care Time.PharmacoEconomics · 2019Review
- Modeling the impact of folic acid fortification and supplementation on red blood cell folate concentrations and predicted neural tube defect risk in the United States: have we reached optimal prevention?The American journal of clinical nutrition · 2018Article
- [Fetal surgery for myelomeningocele: Obstetric evolution and short-term perinatal outcomes of a cohort of 21 cases].Surgical neurology international · 2018Article
- Milestones and controversies in maternal and child health: examining a brief history of micronutrient fortification in the US.Journal of perinatology : official journal of the California Perinatal Association · 2017Review
- Cost-effectiveness of Increasing Access to Contraception during the Zika Virus Outbreak, Puerto Rico, 2016.Emerging infectious diseases · 2017Article
- Using state and provincial surveillance programs to reduce risk of recurrence of neural tube defects in the United States and Canada: A missed opportunity?Birth defects research. Part A, Clinical and molecular teratology · 2016Article
- Retrospective Assessment of Cost Savings From Prevention: Folic Acid Fortification and Spina Bifida in the U.S.American journal of preventive medicine · 2016Article
- Prevalence of congenital defects including selected neural tube defects in Nepal: results from a health survey.BMC pediatrics · 2015Article
- Updated estimates of neural tube defects prevented by mandatory folic Acid fortification - United States, 1995-2011.MMWR. Morbidity and mortality weekly report · 2015Article
- Supplement use and other characteristics among pregnant women with a previous pregnancy affected by a neural tube defect - United States, 1997-2009.MMWR. Morbidity and mortality weekly report · 2015Article
- Epidemiology of neural tube defects in Saudi Arabia.Saudi medical journal · 2014Article
- Estimate of the potential impact of folic acid fortification of corn masa flour on the prevention of neural tube defects.Birth defects research. Part A, Clinical and molecular teratology · 2013Article
- Neural tube defects, folic acid and methylation.International journal of environmental research and public health · 2013Review
- Modelling fortification of corn masa flour with folic acid and the potential impact on Mexican-American women with lower acculturation.Public health nutrition · 2013Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWomen with a pregnancy affected by a neural tube defect (NTD) are encouraged to take folic acid prior to a subsequent pregnancy, but it is unknown whether organized attempts to identify and counsel such women to prevent recurrent NTDs are cost effective.
methodsData from the South Carolina recurrence-prevention program for October 2001-September 2002 were analyzed between October 2002 and December 2003 to calculate costs. Cost-effectiveness modeling of the program during 1992-2006 was conducted during 2007. Results were calculated for three scenarios based on recurrence risk, supplement use, and the effectiveness of folic acid in preventing recurrences. For each scenario, quality-adjusted life years (QALYs) were calculated separately using prevented NTD-affected live births; prevented NTD-affected births (including fetal deaths); and all prevented NTD-affected pregnancies.
resultsThe prevention program cost approximately $155,000 per year in 2003 dollars to protect 35 pregnancies and prevent approximately one NTD. The direct costs associated with an NTD depend on type and outcome, but are approximately $560,000 in 2003 dollars for a live birth with spina bifida. The base-case cost-effectiveness ratio was $39,600 per QALY gained from avoided NTD-affected live births and stillbirths, and $14,700 per QALY gained from the avoidance of all NTD-affected pregnancies. The baseline NTD recurrence risk and the use of folic acid supplements by women who are at high risk for an NTD-affected pregnancy were influential parameters.
conclusionsThe South Carolina NTD recurrence-prevention program appears comparable in cost effectiveness to other preventive services. Other states might consider including NTD recurrence prevention in birth defect-prevention programs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.