ArticleFree radical biology & medicine2008
WR-1065, the active metabolite of amifostine, mitigates radiation-induced delayed genomic instability.
Article in Free radical biology & medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 48 citations in OpenAlex.
- Radioprotective effect of American ginseng on human lymphocytes at 90 minutes postirradiation: a study of 40 cases.Journal of alternative and complementary medicine (New York, N.Y.) · 2010Trial
- Modeling the oxygen effect in DNA strand break induced by gamma-rays with TOPAS-nBio.Physics in medicine and biology · 2024Article
- Amifostine (WR-2721) Mitigates Cognitive Injury Induced by Heavy Ion Radiation in Male Mice and Alters Behavior and Brain Connectivity.Frontiers in physiology · 2021Article
- Metabolic Rewiring in Radiation Oncology Toward Improving the Therapeutic Ratio.Frontiers in oncology · 2021Review
- Gene Activation as a Cell Protection Mechanism Against Gamma-Ray radiation.Journal of lasers in medical sciences · 2020Article
- Radiation-Induced Lung Injury (RILI).Frontiers in oncology · 2019Review
- Cancer Incidence in C3H Mice Protected from Lethal Total-Body Radiation after Amifostine.Radiation research · 2018Article
- The E3 Ligase CHIP Mediates p21 Degradation to Maintain Radioresistance.Molecular cancer research : MCR · 2017Article
- PAFR selectively mediates radioresistance and irradiation-induced autophagy suppression in prostate cancer cells.Oncotarget · 2017Article
- Combating radiation therapy-induced damage to the ovarian environment.Future oncology (London, England) · 2016Review
- Endothelial perturbations and therapeutic strategies in normal tissue radiation damage.Radiation oncology (London, England) · 2014Review
- Radioprotective potential of histamine on rat small intestine and uterus.European journal of histochemistry : EJH · 2012Article
- A mitochondria-targeted inhibitor of cytochrome c peroxidase mitigates radiation-induced death.Nature communications · 2011Article
- SOD2-mediated effects induced by WR1065 and low-dose ionizing radiation on micronucleus formation in RKO human colon carcinoma cells.Radiation research · 2011Article
- Heavy ions, radioprotectors and genomic instability: implications for human space exploration.Radiation and environmental biophysics · 2010Review
- Amifostine metabolite WR-1065 disrupts homologous recombination in mammalian cells.Radiation research · 2010Article
- Low-dose cancer risk modeling must recognize up-regulation of protection.Dose-response : a publication of International Hormesis Society · 2009Article
- Reduction of Delayed Homologous Recombination by Induction of Radioadaptive Response in RaDR-GFP Mice (Yonezawa Effect): An Old Player With a New Role.Dose-response : a publication of International Hormesis SocietyArticle
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Compounds that can protect cells from the effects of radiation are important for clinical use, in the event of an accidental or terrorist-generated radiation event, and for astronauts traveling in space. One of the major concerns regarding the use of radio-protective agents is that they may protect cells initially, but predispose surviving cells to increased genomic instability later. In this study we used WR-1065, the active metabolite of amifostine, to determine how protection from direct effects of high- and low-LET radiation exposure influences genomic stability. When added 30 min before irradiation and in high concentrations, WR-1065 protected cells from immediate radiation-induced effects as well as from delayed genomic instability. Lower, nontoxic concentrations of WR-1065 did not protect cells from death; however, it was effective in significantly decreasing delayed genomic instability in the progeny of irradiated cells. The observed increase in manganese superoxide dismutase protein levels and activity may provide an explanation for this effect. These results confirm that WR-1065 is protective against both low- and high-LET radiation-induced genomic instability in surviving cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.