ArticleGenomics2009
Retinoic acid regulates the human methionine sulfoxide reductase A (MSRA) gene via two distinct promoters.
Article in Genomics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 18 citations in OpenAlex.
- The subcellular distribution of methionine sulfoxide reductase A in mouse and human tissues.Cell and tissue research · 2026Article
- Transcriptome-wide transmission disequilibrium analysis identifies novel risk genes for autism spectrum disorder.PLoS genetics · 2021Article
- The Immune Syntax Revisited: Opening New Windows on Language Evolution.Frontiers in molecular neuroscience · 2015Article
- Thioredoxin and thioredoxin target proteins: from molecular mechanisms to functional significance.Antioxidants & redox signaling · 2013Review
- Methionine sulfoxide reductase A: Structure, function and role in ocular pathology.World journal of biological chemistry · 2011Article
- Identification of a truncated form of Methionine Sulfoxide Reductase A expressed in mouse embryonic stem cells.Journal of biomedical science · 2011Article
- Article
- Methionine sulfoxide reductase B2 is highly expressed in the retina and protects retinal pigmented epithelium cells from oxidative damage.Experimental eye research · 2010Article
- Retinoic acid signaling in mammalian eye development.Experimental eye research · 2009Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
MSRAs (methionine sulfoxide reductases A) are enzymes that reverse the effects of oxidative damage by reducing methionine sulfoxide back to methionine and recovering protein function. In this study we demonstrate that the transcriptional regulation of the human MSRA gene is complex and driven by two distinct promoters. Both promoters demonstrate high expression in human brain and kidney tissues. The upstream (promoter 1) regulates the msrA1 transcript that codes for the mitochondrial form of MSRA and is highly active in a broad range of cell lines. The downstream promoter (promoter 2) regulates the msrA2/3 transcripts that code for the cytosolic/nuclear forms of MSRA and is generally less active. Promoter 2 contains a 65 bp putative enhancer region that is very active in the retinal pigment epithelium-derived D407 cell line. Both promoters are partially regulated by all-trans retinoic acid via RARA and other RARs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.