ArticleDevelopmental biology2008
DNA methyltransferase 1o functions during preimplantation development to preclude a profound level of epigenetic variation.
Article in Developmental biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Pre-implantation alcohol exposure induces lasting sex-specific DNA methylation programming errors in the developing forebrain.Clinical epigenetics · 2021Article
- What impact does oocyte vitrification have on epigenetics and gene expression?Clinical epigenetics · 2020Review
- The preconception environment and sperm epigenetics.Andrology · 2020Review
- Epigenetic Aspects of Engineered Nanomaterials: Is the Collateral Damage Inevitable?Frontiers in bioengineering and biotechnology · 2019Review
- Maternally expressed NLRP2 links the subcortical maternal complex (SCMC) to fertility, embryogenesis and epigenetic reprogramming.Scientific reports · 2017Article
- The Role of Maternal-Effect Genes in Mammalian Development: Are Mammalian Embryos Really an Exception?Stem cell reviews and reports · 2016Review
- Mapping global changes in nuclear cytosine base modifications in the early mouse embryo.Reproduction (Cambridge, England) · 2016Article
- Loss of inherited genomic imprints in mice leads to severe disruption in placental lipid metabolism.Placenta · 2015Article
- Transient DNMT1 suppression reveals hidden heritable marks in the genome.Nucleic acids research · 2015Article
- The DNMT1 intrinsically disordered domain regulates genomic methylation during development.Genetics · 2015Article
- Hydrogen Sulfide Epigenetically Attenuates Homocysteine-Induced Mitochondrial Toxicity Mediated Through NMDA Receptor in Mouse Brain Endothelial (bEnd3) Cells.Journal of cellular physiology · 2015Article
- Partial Loss of Genomic Imprinting Reveals Important Roles for Kcnq1 and Peg10 Imprinted Domains in Placental Development.PloS one · 2015Article
- Comparison of epigenetic mediator expression and function in mouse and human embryonic blastomeres.Human molecular genetics · 2014Article
- Gene expression in teratogenic exposures: a new approach to understanding individual risk.Reproductive toxicology (Elmsford, N.Y.) · 2014Article
- Loss of DNMT1o disrupts imprinted X chromosome inactivation and accentuates placental defects in females.PLoS genetics · 2013Article
- Generalized disruption of inherited genomic imprints leads to wide-ranging placental defects and dysregulated fetal growth.Developmental biology · 2013Article
- Genomic imprinting: recognition and marking of imprinted loci.Current opinion in genetics & development · 2012Review
- Mouse ES cells overexpressing DNMT1 produce abnormal neurons with upregulated NMDA/NR1 subunit.Differentiation; research in biological diversity · 2011Article
- Mammalian genomic imprinting.Cold Spring Harbor perspectives in biology · 2011Review
- Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Most mouse embryos developing in the absence of the oocyte-derived DNA methyltransferase 1o (DNMT1o-deficient embryos) have significant delays in development and a wide range of anatomical abnormalities. To understand the timing and molecular basis of such variation, we studied pre- and post-implantation DNA methylation as a gauge of epigenetic variation among these embryos. DNMT1o-deficient embryos showed extensive differences in the levels of methylation in differentially methylated domains (DMDs) of imprinted genes at the 8-cell stage. Because of independent assortment of the methylated and unmethylated chromatids created by the loss of DNMT1o, the deficient embryos were found to be mosaics of cells with different, but stable epigenotypes (DNA methylation patterns). Our results suggest that loss of DNMT1o in just one cell cycle is responsible for the extensive variation in the epigenotypes in both embryos and their associated extraembryonic tissues. Thus, the maternal-effect DNMT1o protein is uniquely poised during development to normally ensure uniform parental methylation patterns at DMDs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.